3087879-97-5
3087879-97-5
Chemical Structure
ZS3-046
- CAS No.: 3087879-97-5
- Formula:C49H57N9O7
- Molecular Weight:884.03
InChIKey: KASNHHJUUMTBAP-UHFFFAOYSA-N
SMILES: O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
Biological Activity: ZS3-046 is a potent TAF1 PROTAC degrader with a DC50 < 10 nM. ZS3-046 recruits the CRBN E3 ubiquitin ligase, promotes polyubiquitination and proteasomal degradation of TAF1, thereby activating p53 and downregulating c-Myc, and ultimately induces apoptosis of tumor cells. ZS3-046 can be used in research related to acute myeloid leukemia[1].
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ZS3-046 | ZS3-046 is a potent TAF1 PROTAC degrader with a DC50 < 10 nM. ZS3-046 recruits the CRBN E3 ubiquitin ligase, promotes polyubiquitination and proteasomal degradation of TAF1, thereby activating p53 and downregulating c-Myc, and ultimately induces apoptosis of tumor cells. ZS3-046 can be used in research related to acute myeloid leukemia. | |||||||||||||||||||||
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