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Cat. No.: HY-151014

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KRAS ligand 1

KRAS ligand 1 is a KRAS^G12C ligand and can be used for the synthesis of PROTACs, such as PROTAC KRAS G12C degrader-1 (HY-139186).

For research use only. We do not sell to patients.

CAS No.: 1698025-19-2
Formula: C₂₅H₂₀ClFN₄O₂
Molecular Weight:462.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS ligand 1 Chemical Structure

CAS No.: 1698025-19-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Description

KRAS ligand 1 is a KRAS^G12C ligand and can be used for the synthesis of PROTACs, such as PROTAC KRAS G12C degrader-1 (HY-139186)^[1].

IC₅₀ & Target

^[1]

KRas G12C

All Ras Isoforms :

In Vitro

The ligand for the target protein causes the PROTAC to attach to the target protein, leading to its ubiquitination and subsequent degradation.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1698025-19-2
Molecular Weight 462.90
Formula C₂₅H₂₀ClFN₄O₂
SMILES

ClC(C=C1C(N=CN=C1N2CCN(C(C=C)=O)CC2)=C3F)=C3C4=CC(O)=CC5=CC=CC=C54
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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KRAS ligand 1

All Ras Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS ligand 1 Related Classifications

HY-151014 Related Classifications

Bioz

Keywords

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