Pomalidomide-amino-PEG5-NH2 hydrochloride

Name: Pomalidomide-amino-PEG5-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-133816
Rating: 4.5 (0 reviews)

Cat. No.: HY-133816 Purity: 99.58%: Data Sheet
COA

SDS
Handling Instructions
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Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Pomalidomide-amino-PEG5-NH2 hydrochloride 화학구조

CAS No. : 2421217-05-0

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Pomalidomide-amino-PEG5-NH2 hydrochloride:

Pomalidomide-amino-PEG5-NH2 견적 받기

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

587.02

화학식

C₂₅H₃₅ClN₄O₁₀

CAS No.

2421217-05-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCOCCOCCN.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 105 mg/mL (178.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7035 mL	8.5176 mL	17.0352 mL
5 mM	0.3407 mL	1.7035 mL	3.4070 mL
10 mM	0.1704 mL	0.8518 mL	1.7035 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.58%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (284 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7035 mL	8.5176 mL	17.0352 mL	42.5880 mL
	5 mM	0.3407 mL	1.7035 mL	3.4070 mL	8.5176 mL
	10 mM	0.1704 mL	0.8518 mL	1.7035 mL	4.2588 mL
	15 mM	0.1136 mL	0.5678 mL	1.1357 mL	2.8392 mL
	20 mM	0.0852 mL	0.4259 mL	0.8518 mL	2.1294 mL
	25 mM	0.0681 mL	0.3407 mL	0.6814 mL	1.7035 mL
	30 mM	0.0568 mL	0.2839 mL	0.5678 mL	1.4196 mL
	40 mM	0.0426 mL	0.2129 mL	0.4259 mL	1.0647 mL
	50 mM	0.0341 mL	0.1704 mL	0.3407 mL	0.8518 mL
	60 mM	0.0284 mL	0.1420 mL	0.2839 mL	0.7098 mL
	80 mM	0.0213 mL	0.1065 mL	0.2129 mL	0.5323 mL
	100 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.4259 mL