1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. (S,R,S)-AHPC-Me-C10-NH2

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).

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(S,R,S)-AHPC-Me-C10-NH2 Chemical Structure

(S,R,S)-AHPC-Me-C10-NH2 Chemical Structure

CAS No. : 2376139-52-3

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Description

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602)[1].

IC50 & Target[1]

VHL

 

In Vitro

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

627.88

Formula

C34H53N5O4S

CAS No.
Appearance

Solid

Color

Light brown to orange

SMILES

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCCCCCCCN)=O)C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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(S,R,S)-AHPC-Me-C10-NH2 Related Classifications

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Product Name:
(S,R,S)-AHPC-Me-C10-NH2
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HY-130847
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