Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc

Cat. No.: HY-145177: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7).

For research use only. We do not sell to patients.

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Chemical Structure

CAS No. : 1799711-31-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cereblon

Molecular Weight

634.67

Formula

C₃₀H₄₂N₄O₁₁

CAS No.

1799711-31-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCOCCOCCOCCCNC(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (157.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5756 mL	7.8781 mL	15.7562 mL
5 mM	0.3151 mL	1.5756 mL	3.1512 mL
10 mM	0.1576 mL	0.7878 mL	1.5756 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shaomeng Wang, et al. Bet protein degraders. WO2017180417A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5756 mL	7.8781 mL	15.7562 mL	39.3906 mL
	5 mM	0.3151 mL	1.5756 mL	3.1512 mL	7.8781 mL
	10 mM	0.1576 mL	0.7878 mL	1.5756 mL	3.9391 mL
	15 mM	0.1050 mL	0.5252 mL	1.0504 mL	2.6260 mL
	20 mM	0.0788 mL	0.3939 mL	0.7878 mL	1.9695 mL
	25 mM	0.0630 mL	0.3151 mL	0.6302 mL	1.5756 mL
	30 mM	0.0525 mL	0.2626 mL	0.5252 mL	1.3130 mL
	40 mM	0.0394 mL	0.1970 mL	0.3939 mL	0.9848 mL
	50 mM	0.0315 mL	0.1576 mL	0.3151 mL	0.7878 mL
	60 mM	0.0263 mL	0.1313 mL	0.2626 mL	0.6565 mL
	80 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.4924 mL
	100 mM	0.0158 mL	0.0788 mL	0.1576 mL	0.3939 mL