Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc

製品番号: HY-145177 純度: 98.43%: Data Sheet SDS COA 取扱説明書
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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7).

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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc 構造式

CAS 番号 : 1799711-31-1

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 101	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 101	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$72	在庫あり	Estimated Time of Arrival: December 31
10 mg	$120	在庫あり	Estimated Time of Arrival: December 31
25 mg	$253	在庫あり	Estimated Time of Arrival: December 31
50 mg	$406	在庫あり	Estimated Time of Arrival: December 31
100 mg	$650	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

Cereblon

分子量

634.67

分子式

C₃₀H₄₂N₄O₁₁

CAS 番号

1799711-31-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCOCCOCCOCCCNC(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O)OC(C)(C)C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (157.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5756 mL	7.8781 mL	15.7562 mL
5 mM	0.3151 mL	1.5756 mL	3.1512 mL
10 mM	0.1576 mL	0.7878 mL	1.5756 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.43%

Select Batch:

データシート (267 KB) SDS (252 KB)

COA (242 KB) HNMR (402 KB) LCMS (88 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Shaomeng Wang, et al. Bet protein degraders. WO2017180417A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5756 mL	7.8781 mL	15.7562 mL	39.3906 mL
	5 mM	0.3151 mL	1.5756 mL	3.1512 mL	7.8781 mL
	10 mM	0.1576 mL	0.7878 mL	1.5756 mL	3.9391 mL
	15 mM	0.1050 mL	0.5252 mL	1.0504 mL	2.6260 mL
	20 mM	0.0788 mL	0.3939 mL	0.7878 mL	1.9695 mL
	25 mM	0.0630 mL	0.3151 mL	0.6302 mL	1.5756 mL
	30 mM	0.0525 mL	0.2626 mL	0.5252 mL	1.3130 mL
	40 mM	0.0394 mL	0.1970 mL	0.3939 mL	0.9848 mL
	50 mM	0.0315 mL	0.1576 mL	0.3151 mL	0.7878 mL
	60 mM	0.0263 mL	0.1313 mL	0.2626 mL	0.6565 mL
	80 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.4924 mL
	100 mM	0.0158 mL	0.0788 mL	0.1576 mL	0.3939 mL