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Cat. No.: HY-125906

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VHL Ligand-Linker Conjugates 15

Name: VHL Ligand-Linker Conjugates 15
Brand: MedChemExpress
SKU: HY-125906
Availability: PreOrder

(Synonyms: E3 Ligase Ligand-Linker Conjugates 56)

VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs.

For research use only. We do not sell to patients.

CAS No.: 2375564-62-6
Formula: C₃₇H₄₅FN₄O₈S
Molecular Weight:724.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

VHL Ligand-Linker Conjugates 15 Chemical Structure

CAS No.: 2375564-62-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs^[1].

IC₅₀ & Target^[1]

VHL

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2375564-62-6
Molecular Weight 724.84
Formula C₃₇H₄₅FN₄O₈S
SMILES

O=C(NCC1=CC=C(C=C1OCCOC2=CC=C(C=C2)C3OCCO3)C4=C(N=CS4)C)[C@H]5N(C[C@@H](C5)O)C([C@H](C(C)(C)C)NC(C6(CC6)F)=O)=O
Synonyms

E3 Ligase Ligand-Linker Conjugates 56
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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VHL Ligand-Linker Conjugates 15

All E3 Ligase Ligand-Linker Conjugates Isoforms