1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-C2-amido-C2-COOH

Thalidomide-C2-amido-C2-COOH 

Cat. No.: HY-130713
Handling Instructions

Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709).

For research use only. We do not sell to patients.

Thalidomide-C2-amido-C2-COOH Chemical Structure

Thalidomide-C2-amido-C2-COOH Chemical Structure

CAS No. : 2353496-84-9

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Description

Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709)[1].

IC50 & Target

Cereblon

 

Molecular Weight

416.38

Formula

C₁₉H₂₀N₄O₇

CAS No.

2353496-84-9

SMILES

O=C(O)CCC(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Thalidomide-C2-amido-C2-COOHE3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Thalidomide-C2-amido-C2-COOH
Cat. No.:
HY-130713
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