1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. E3 ligase Ligand-Linker Conjugates 51

E3 ligase Ligand-Linker Conjugates 51 

Cat. No.: HY-125846
Handling Instructions

E3 ligase Ligand-Linker Conjugates 51 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 51 can be used to design BCR-ABL1 PROTAC degrader GMB-475. GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

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E3 ligase Ligand-Linker Conjugates 51 Chemical Structure

E3 ligase Ligand-Linker Conjugates 51 Chemical Structure

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Description

E3 ligase Ligand-Linker Conjugates 51 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 51 can be used to design BCR-ABL1 PROTAC degrader GMB-475. GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target[1]

VHL

 

Molecular Weight

546.68

Formula

C₂₇H₃₈N₄O₆S

SMILES

COCCOCC(N[[email protected]](C(C)(C)C)C(N1[[email protected]](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O)=O

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E3 ligase Ligand-Linker Conjugates 51
Cat. No.:
HY-125846
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