Thalidomide-NH-(CH2)2-NH2 TFA
Based on 1 Customer Validation
Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-NH-(CH2)2-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules designed to synthesize small PROTAC molecules targeting SHP2 protein.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 1957235-67-4
- Formula: C17H17F3N4O6
- Molecular Weight:430.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EA.hy 926 | IC50 |
150 μM
Compound: 10
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Antiproliferative activity against human EAhy926 cells
Antiproliferative activity against human EAhy926 cells
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[PMID: 19103485] |
Chemical Information
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CAS No. 1957235-67-4
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Appearance Solid
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Molecular Weight 430.34
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Formula C17H17F3N4O6
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCN)=O.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)