1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Potassium Channel
    GABA Receptor
  3. 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid 

Cat. No.: HY-133596
Handling Instructions

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.

For research use only. We do not sell to patients.

12,14-Dichlorodehydroabietic acid Chemical Structure

12,14-Dichlorodehydroabietic acid Chemical Structure

CAS No. : 65281-77-8

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Description

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

IC50 & Target

Ca2+-activated K+ (BK) channel[2]
GABAA[1]

Molecular Weight

369.33

Formula

C₂₀H₂₆Cl₂O₂

CAS No.

65281-77-8

SMILES

O=C([[email protected]]1(C)CCC[[email protected]]2(C)C3=C(CC[[email protected]@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

12,14-Dichlorodehydroabietic acidPotassium ChannelGABA ReceptorKcsAGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorChlorinatedresinacidCa2+transmitterGABAABKα,Inhibitorinhibitorinhibit

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12,14-Dichlorodehydroabietic acid
Cat. No.:
HY-133596
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