12,14-Dichlorodehydroabietic acid
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.
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- CAS No.: 65281-77-8
- Formula: C20H26Cl2O2
- Molecular Weight:369.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 65281-77-8
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Molecular Weight 369.33
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Formula C20H26Cl2O2
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SMILES
O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32. [Content Brief]
[2]. Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
12,14-Dichlorodehydroabietic acid Related Classifications
HY-133596 Related Classifications
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