Etomoxir sodium salt
Based on 149 publication(s) in Google Scholar
Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 828934-41-4
- Formula: C15H18ClNaO4
- Molecular Weight:320.74
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
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Publications Citing Use of MedChemExpress (MCE) Etomoxir sodium salt
More- Cancer Cell. 2026 Feb 9;44(2):383-404.e18. [Abstract]
- Cancer Cell. 2025 Apr 22:S1535-6108(25)00138-2. [Abstract]
- Cell Metab. 2026 Apr 29:S1550-4131(26)00142-7. [Abstract]
- Cell Metab. 2024 May 7;36(5):969-983.e10. [Abstract]
- Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. [Abstract]
- Cell Metab. 2022 Nov 1;34(11):1843-1859.e11. [Abstract]
- Nat Metab. 2025 Sep 30. [Abstract]
- Nat Metab. 2022 Oct;4(10):1287-1305. [Abstract]
- Nat Genet. 2025 Mar;57(3):680-693. [Abstract]
- Cell Stem Cell. 2025 Dec 4;32(12):1849-1868.e15. [Abstract]
- Cancer Res. 2026 Apr 29:10.1158/0008-5472.CAN-24-1984. [Abstract]
- Cancer Res. 2023 Aug 1;83(15):2461-2470. [Abstract]
- Clin Mol Hepatol. 2024 Jul;30(3):515-538. [Abstract]
- Autophagy. 2026 May 27:1-27. [Abstract]
- Autophagy. 2025 Jan;21(1):80-101. [Abstract]
- Nat Commun. 2025 May 15;16(1):4502. [Abstract]
- Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]
- Nat Commun. 2025 Jan 2;16(1):212. [Abstract]
- Nat Commun. 2024 Aug 3;15(1):6587. [Abstract]
- Nat Commun. 2024 May 7;15(1):3805. [Abstract]
- Nat Commun. 2022 Jun 17;13(1):3486. [Abstract]
- Nat Commun. 2021 Jun 16;12(1):3660. [Abstract]
- Hepatology. 2022 Dec;76(6):1617-1633. [Abstract]
- Sci Immunol. 2023 Sep 29;8(87):eabq2424. [Abstract]
- Redox Biol. 2021 Oct:46:102082. [Abstract]
- Redox Biol. 2018 Oct:19:412-428. [Abstract]
- Redox Biol. 2018 Jul:17:180-191. [Abstract]
- Mol Cell. 2024 Jul 11;84(13):2436-2454.e10. [Abstract]
- Mol Cell. 2022 Aug 18;82(16):3030-3044.e8. [Abstract]
- Mol Cell. 2020 Oct 1;80(1):43-58.e7. [Abstract]
- Theranostics. 2020 May 16;10(14):6483-6499. [Abstract]
- Genes Dis. 2026 Mar 27.
- Acta Pharm Sin B. 2025 Jan;15(1):256-277. [Abstract]
- Adv Sci (Weinh). 2026 Jun 15:e76109. [Abstract]
- Adv Sci (Weinh). 2025 Nov 6:e07384. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(3):e2411559. [Abstract]
- Cell Rep Med. 2025 Dec 16;6(12):102507. [Abstract]
- Cell Rep Med. 2024 Jun 18;5(6):101592. [Abstract]
- Sci Adv. 2025 Aug 29;11(35):eadu6271. [Abstract]
- Sci Adv. 2023 Apr 14;9(15):eadf8522. [Abstract]
- Brain. 2025 Mar 6;148(3):788-802. [Abstract]
- Cell Death Dis. 2026 Jun 9. [Abstract]
- Cell Death Dis. 2025 Apr 14;16(1):291. [Abstract]
- Engineering. 2024 Sep 6.
- Cell Death Dis. 2023 Oct 6;14(10):653. [Abstract]
- Cell Death Dis. 2023 Feb 15;14(2):125. [Abstract]
- Cell Death Dis. 2022 Mar 11;13(3):229. [Abstract]
- Pharmacol Res. 2021 Oct:172:105796. [Abstract]
- Cancer Lett. 2024 Aug 10:597:217068. [Abstract]
- J Immunother Cancer. 2025 Oct 23;13(10):e012162. [Abstract]
- Int J Biol Sci. 2025 Jan 1;21(2):725-744. [Abstract]
- Int J Biol Sci. 2022 Mar 14;18(6):2484-2496. [Abstract]
- Int J Biol Sci. 2021 Oct 11;17(15):4207-4222. [Abstract]
- Acta Pharmacol Sin. 2025 May 20. [Abstract]
- Cell Death Discov. 2024 May 1;10(1):207. [Abstract]
- Acta Biomater. 2022 Sep 15:150:83-95. [Abstract]
- Biomater Res. 2026 Apr 29.
- Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2105950118. [Abstract]
- Dev Cell. 2025 Apr 18:S1534-5807(25)00206-0. [Abstract]
- Oncogene. 2025 Sep;44(34):3096-3112. [Abstract]
- Arterioscler Thromb Vasc Biol. 2025 Aug 21. [Abstract]
- Mol Med. 2025 Oct 9;31(1):310. [Abstract]
- Antioxidants (Basel). 2026 Jun 15;15(6):754. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2025;19(10):101539. [Abstract]
- Free Radic Biol Med. 2026 Mar 1:245:343-356. [Abstract]
- Free Radic Biol Med. 2022 Sep:190:94-104. [Abstract]
- Free Radic Biol Med. 2019 Sep:141:372-382. [Abstract]
- Clin Transl Med. 2022 Sep;12(9):e1061. [Abstract]
- Stem Cell Res Ther. 2024 Sep 27;15(1):328. [Abstract]
- Aging Cell. 2024 Aug;23(8):e14184. [Abstract]
- Cell Rep. 2024 Feb 27;43(2):113739. [Abstract]
- Cell Rep. 2021 Sep 7;36(10):109659. [Abstract]
- Cell Rep. 2019 Apr 2;27(1):226-237.e4. [Abstract]
- Cell Prolif. 2026 Apr 27:e70216. [Abstract]
- Cell Prolif. 2026 Apr 28:e70215. [Abstract]
- Cell Prolif. 2021 Nov;54(11):e13134. [Abstract]
- Cancer Cell Int. 2025 May 14;25(1):176. [Abstract]
- J Invest Dermatol. 2023 Oct;143(10):1993-2006.e10. [Abstract]
- Cancer Cell Int. 2023 May 9;23(1):87. [Abstract]
- Front Immunol. 2022 Mar 10;13:771732. [Abstract]
- PLoS Biol. 2026 Mar 12;24(3):e3003698. [Abstract]
- PLoS Biol. 2025 Nov 24;23(11):e3003490. [Abstract]
- Lipids Health Dis. 2024 Feb 3;23(1):37. [Abstract]
- J Agric Food Chem. 2024 Jun 12;72(23):13039-13053. [Abstract]
- CNS Neurosci Ther. 2026 Jan;32(1):e70744. [Abstract]
- Life Sci. 2026 Sep 15:401:124529. [Abstract]
- Life Sci. 2024 Aug 1:350:122763. [Abstract]
- Mol Metab. 2024 Jun:84:101953. [Abstract]
- J Cell Biol. 2022 Dec 5;221(12):e202207022. [Abstract]
- Commun Biol. 2026 May 26. [Abstract]
- Cell Rep Methods. 2026 May 18;6(5):101413. [Abstract]
- Commun Biol. 2022 Dec 7;5(1):1340. [Abstract]
- Respir Res. 2026 May 9. [Abstract]
- Am J Physiol Cell Physiol. 2025 Mar 1;328(3):C776-C790. [Abstract]
- Front Pharmacol. 2022 May 16;13:848957. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Oct;1871(7):167919. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167314. [Abstract]
- PLoS Pathog. 2026 Apr 24;22(4):e1014170. [Abstract]
- Ann Med. 2025 Dec;57(1):2497112. [Abstract]
- Sci Rep. 2025 Aug 20;15(1):30552. [Abstract]
- Sci Rep. 2024 Jan 18;14(1):1600. [Abstract]
- Neoplasia. 2025 Mar:61:101125. [Abstract]
- Eur J Med Res. 2025 Jan 17;30(1):35. [Abstract]
- Med Oncol. 2025 Jul 14;42(8):332. [Abstract]
- Cell Signal. 2025 Apr:128:111627. [Abstract]
- Rheumatology (Oxford). 2024 Sep 1;63(9):2578-2589. [Abstract]
- Oncol Rep. 2023 Jul;50(1):138. [Abstract]
- Oncol Rep. 2023 Jul;50(1):141. [Abstract]
- FASEB J. 2026 Jun 30;40(12):e72060. [Abstract]
- Biology (Basel). 2025 Dec 31;15(1):85. [Abstract]
- FASEB J. 2025 Mar 15;39(5):e70439. [Abstract]
- Fish Shellfish Immunol. 2024 Oct:153:109829. [Abstract]
- Antimicrob Agents Chemother. 2018 Apr 26;62(5):e01659-17. [Abstract]
- J Biol Chem. 2026 May 22;302(7):113179. [Abstract]
- Eur J Immunol. 2025 Dec;55(12):e70087. [Abstract]
- J Biol Chem. 2024 Aug;300(8):107549. [Abstract]
- Front Biosci (Landmark Ed). 2024 Feb 6;29(2):66. [Abstract]
- J Cell Sci. 2022 Aug 1;135(15):jcs259090. [Abstract]
- Vet Res. 2026 May 9;57(1):72. [Abstract]
- J Orthop Surg Res. 2023 May 26;18(1):386. [Abstract]
- J Biomed Mater Res A. 2022 Aug;110(8):1448-1459. [Abstract]
- Mol Immunol. 2026 Apr:192:32-44. [Abstract]
- Cell Biol Int. 2024 Sep;48(9):1378-1391. [Abstract]
- Front Oncol. 2021 Apr 22:11:665763. [Abstract]
- Biol Reprod. 2026 Apr 16:ioag080. [Abstract]
- Food Chem Toxicol. 2022 Nov:169:113450. [Abstract]
- Am J Physiol Gastrointest Liver Physiol. 2025 Apr 17. [Abstract]
- Vet Microbiol. 2024 Jan:288:109932. [Abstract]
- Infect Genet Evol. 2020 Nov:85:104552. [Abstract]
- Clin Transl Oncol. 2025 Jun;27(6):2557-2567. [Abstract]
- Biochem Biophys Res Commun. 2021 Oct 8:583:135-141. [Abstract]
- Cell Physiol Biochem. 2018;48(6):2318-2336. [Abstract]
- Biochem Biophys Res Commun. 2017 Feb 5;483(2):860-866. [Abstract]
- Res Sq. 2026 Jun 15.
- bioRxiv. 2026 Jun 1.
- bioRxiv. 2026 May 22.
- Johns Hopkins University. 2025 Sep.
- bioRxiv. 2025 May 15.
- bioRxiv. 2025 April 10.
- bioRxiv. 2023 Nov 17.
- Research Square Preprint. 2023 Aug 1.
- bioRxiv. 2023 Apr 17.
- Research (Wash D C). 2023:6:0087. [Abstract]
- SSRN. 6 Dec 2022.
- Research Square Preprint. 2022 Feb.
- Universidade de São Paulo. Ribeirão Preto, 2021.
- bioRxiv. 2021 Mar 8.
- Research Square Preprint. 2020 Sep.
- Oncotarget. 2016 Oct 11;7(41):67071-67086. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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WB
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
Biological Activity
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CPT-1A |
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells[2].
Etomoxir does not affect the activities of the cardiolipin biosynthetic and remodeling enzymes but causes a reduction in [1-14C]palmitic acid or [1-14C]oleic acid incorporation into cardiolipin[2].
Etomoxir increases [1,3-3H]glycerol incorporation into cardiolipin. The mechanism is a 33% increase in glycerol kinase activity, which produces an increased glycerol flux through the de novo pathway of cardiolipin biosynthesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat heart H9c2 myoblastic cells
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Concentration:1-80 μM
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Incubation Time:2 hours
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Result:Reduced the incorporation of [1-14C]fatty acids into CL and PtdGro in H9c2 cardiac myoblast cells but did not affect total incorporation of radioactivity into these cells.
Etomoxir inhibits the increase of mitochondrial ROS generation in db/db and HF-fed mice and osteoblasts[3].
Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates[4]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:80 male C57BLKS/J lar-Leprdb/db mice[3]
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Dosage:1 mg/kg
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Administration:Intraperitoneally injected; twice every week
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Result:Serum alkaline phosphatase was increased in db/db mice, which event was significantly suppressed by Etomoxir. Serum level of osteocalcin, a marker of bone formation, was reduced in db/db mice and Etomoxir markedly inhibited the reduction of osteocalcin. Serum tartrate-resistant acid phosphatase was elevated in db/db mice which phenomenon was significantly suppressed by Etomoxir.
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Animal Model:Rats[4]
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Dosage:20 mg/kg
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Administration:Injected daily; for 8 days
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Result:Etomoxir-treated rats displayed a 44% reduced cardiac CPT-I activity.
Chemical Information
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CAS No. 828934-41-4
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Appearance Solid
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Molecular Weight 320.74
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Formula C15H18ClNaO4
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Color White to off-white
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SMILES
ClC1=CC=C(OCCCCCC[C@@]2(CO2)C(O[Na])=O)C=C1
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Synonyms
(R)-(+)-Etomoxir sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
Publications (149)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma. [Abstract]2026 Feb 9;44(2):383-404.e18. PMID: 41544627 -
Cancer Cell
2025 Apr 22:S1535-6108(25)00138-2. PMID: 40280124
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Apr 22:S1535-6108(25)00138-2. [Abstract]
Relative confluence of A375 cells treated with young secretome (YA, blue) and YA secretome containing Etomoxir (10 µM; 40 h) (YA Etomoxir, white circles).
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Cell Metab
NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis. [Abstract]2026 Apr 29:S1550-4131(26)00142-7. PMID: 42061402 -
Cell Metab
Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment. [Abstract]2024 May 7;36(5):969-983.e10. PMID: 38490211
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 May 7;36(5):969-983.e10. [Abstract]
Etomoxir (10 mM; 20 min). Energetic profiling, OCR trace with SRC quantifications of OT-1 T cells cultured ± ACCi.
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Cell Metab
2023 Dec 5;35(12):2136-2152.e9. PMID: 37989315
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. [Abstract]
Etomoxir（50 μM; 6 days）.Seahorse respirometry and measurement of the oxygen consumption rate (OCR) in WT (D and F) or Lepr-cKO (E) nerve explants.
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Cell Metab
2022 Nov 1;34(11):1843-1859.e11. PMID: 36103895 -
Nat Metab
2025 Sep 30. PMID: 41028912
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 30. [Abstract]
Luminescence detection of intracellular ATP (a.u., arbitrary units) in cultured hippocampal E16 Ddhd2−/− neurons ±1 µM M-CoA for 48 h and ± etomoxir (1 μM; 48 h) analysed at DIV 21–22 normalized to the average of Ddhd2−/− in each experiment.
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Nat Metab
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance. [Abstract]2022 Oct;4(10):1287-1305. PMID: 36203054 -
Nat Genet
2025 Mar;57(3):680-693. PMID: 40069506
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693. [Abstract]
A375 cells treated with IFN-γ and Etomoxir (100,200 μM; 24 h) were analyzed for PD-L1 expression.
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Cell Stem Cell
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages. [Abstract]2025 Dec 4;32(12):1849-1868.e15. PMID: 41205597 -
Cancer Res
KRAS Signaling Inhibition Induces a Targetable Metabolic Dependency on Lipophagy-Dependent Fatty Acid Oxidation in Pancreatic Cancer. [Abstract]2026 Apr 29:10.1158/0008-5472.CAN-24-1984. PMID: 42054558 -
Cancer Res
Oxidative phosphorylation fueled by fatty acid oxidation sensitizes leukemic stem cells to cold. [Abstract]2023 Aug 1;83(15):2461-2470. PMID: 37272750 -
Clin Mol Hepatol
2024 Jul;30(3):515-538. PMID: 38726504 -
Autophagy
PRRSV NSP2 hijacks host lipophagy via a LIPE-PNPLA2-AMPK-MTOR axis to promote viral replication. [Abstract]2026 May 27:1-27. PMID: 42200529 -
Autophagy
MANF facilitates breast cancer cell survival under glucose-starvation conditions via prkn-mediated mitophagy regulation. [Abstract]2025 Jan;21(1):80-101. PMID: 39147386 -
Nat Commun
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis. [Abstract]2025 May 15;16(1):4502. PMID: 40374622 -
Nat Commun
Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism. [Abstract]2025 Feb 1;16(1):1241. PMID: 39890808 -
Nat Commun
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation. [Abstract]2025 Jan 2;16(1):212. PMID: 39747079 -
Nat Commun
2024 Aug 3;15(1):6587. PMID: 39097623 -
Nat Commun
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma. [Abstract]2024 May 7;15(1):3805. PMID: 38714664 -
Nat Commun
2022 Jun 17;13(1):3486. PMID: 35710796 -
Nat Commun
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. [Abstract]2021 Jun 16;12(1):3660. PMID: 34135321 -
Hepatology
Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids. [Abstract]2022 Dec;76(6):1617-1633. PMID: 35030285 -
Sci Immunol
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors. [Abstract]2023 Sep 29;8(87):eabq2424. PMID: 37738362 -
Redox Biol
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]2021 Oct:46:102082. PMID: 34343908 -
Redox Biol
Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation. [Abstract]2018 Oct:19:412-428. PMID: 30241032 -
Redox Biol
Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells. [Abstract]2018 Jul:17:180-191. PMID: 29702405 -
Mol Cell
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism. [Abstract]2024 Jul 11;84(13):2436-2454.e10. PMID: 38925114 -
Mol Cell
An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. [Abstract]2022 Aug 18;82(16):3030-3044.e8. PMID: 35764091 -
Mol Cell
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation. [Abstract]2020 Oct 1;80(1):43-58.e7. PMID: 32937100 -
Theranostics
STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma. [Abstract]2020 May 16;10(14):6483-6499. PMID: 32483465 -
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Acta Pharm Sin B
Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation. [Abstract]2025 Jan;15(1):256-277. PMID: 40041918 -
Adv Sci (Weinh)
Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy. [Abstract]2026 Jun 15:e76109. PMID: 42294812 -
Adv Sci (Weinh)
Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke. [Abstract]2025 Nov 6:e07384. PMID: 41195589 -
Adv Sci (Weinh)
2025 Jan;12(3):e2411559. PMID: 39587975 -
Cell Rep Med
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization. [Abstract]2025 Dec 16;6(12):102507. PMID: 41406945 -
Cell Rep Med
A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. [Abstract]2024 Jun 18;5(6):101592. PMID: 38843841 -
Sci Adv
Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia. [Abstract]2025 Aug 29;11(35):eadu6271. PMID: 40880474 -
Sci Adv
M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism. [Abstract]2023 Apr 14;9(15):eadf8522. PMID: 37058562 -
Brain
2025 Mar 6;148(3):788-802. PMID: 39197036 -
Cell Death Dis
2026 Jun 9. PMID: 42265088 -
Cell Death Dis
A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis. [Abstract]2025 Apr 14;16(1):291. PMID: 40229247 -
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Cell Death Dis
Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer. [Abstract]2023 Oct 6;14(10):653. PMID: 37803002 -
Cell Death Dis
NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation. [Abstract]2023 Feb 15;14(2):125. PMID: 36792587
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 15;14(2):125. [Abstract]
Etomoxir reduces the proliferation of 143b cells.
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Cell Death Dis
2022 Mar 11;13(3):229. PMID: 35277475 -
Pharmacol Res
2021 Oct:172:105796. PMID: 34343656 -
Cancer Lett
2024 Aug 10:597:217068. PMID: 38901665 -
J Immunother Cancer
CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation. [Abstract]2025 Oct 23;13(10):e012162. PMID: 41135952 -
Int J Biol Sci
Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation. [Abstract]2025 Jan 1;21(2):725-744. PMID: 39781464 -
Int J Biol Sci
Acyl-CoA synthetase long-chain 3-mediated fatty acid oxidation is required for TGFβ1-induced epithelial-mesenchymal transition and metastasis of colorectal carcinoma. [Abstract]2022 Mar 14;18(6):2484-2496. PMID: 35414781 -
Int J Biol Sci
Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer. [Abstract]2021 Oct 11;17(15):4207-4222. PMID: 34803493 -
Acta Pharmacol Sin
STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation. [Abstract]2025 May 20. PMID: 40394235 -
Cell Death Discov
TM7SF2-induced lipid reprogramming promotes cell proliferation and migration via CPT1A/Wnt/β-Catenin axis in cervical cancer cells. [Abstract]2024 May 1;10(1):207. PMID: 38693136 -
Acta Biomater
2022 Sep 15:150:83-95. PMID: 35917912 -
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Proc Natl Acad Sci U S A
2021 Nov 16;118(46):e2105950118. PMID: 34772808 -
Dev Cell
2025 Apr 18:S1534-5807(25)00206-0. PMID: 40280135 -
Oncogene
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation. [Abstract]2025 Sep;44(34):3096-3112. PMID: 40595416 -
Arterioscler Thromb Vasc Biol
TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma. [Abstract]2025 Aug 21. PMID: 40836919 -
Mol Med
Dysfunctional glycolysis-UCP2-fatty acid oxidation promotes CTLA4intFOXP3int regulatory T-cell production in rheumatoid arthritis. [Abstract]2025 Oct 9;31(1):310. PMID: 41068616 -
Antioxidants (Basel)
Cannabigerol and Cannabichromene Induce Lung Cancer Cell Death and Apoptosis-Contribution of PPARα to Cannabigerol Effects. [Abstract]2026 Jun 15;15(6):754. PMID: 42352060 -
Cell Mol Gastroenterol Hepatol
2025;19(10):101539. PMID: 40409684 -
Free Radic Biol Med
2026 Mar 1:245:343-356. PMID: 41500341 -
Free Radic Biol Med
Inhibition of mitochondrial superoxide promotes the development of hiPS-CMs during differentiation. [Abstract]2022 Sep:190:94-104. PMID: 35952922 -
Free Radic Biol Med
Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress. [Abstract]2019 Sep:141:372-382. PMID: 31291602 -
Clin Transl Med
PARK7 deficiency inhibits fatty acid β-oxidation via PTEN to delay liver regeneration after hepatectomy. [Abstract]2022 Sep;12(9):e1061. PMID: 36149763 -
Stem Cell Res Ther
Adipose stem cells regulate lipid metabolism by upregulating mitochondrial fatty acid β-oxidation in macrophages to improve the retention rate of transplanted fat. [Abstract]2024 Sep 27;15(1):328. PMID: 39334483 -
Aging Cell
PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease. [Abstract]2024 Aug;23(8):e14184. PMID: 38687090 -
Cell Rep
GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity. [Abstract]2024 Feb 27;43(2):113739. PMID: 38340319 -
Cell Rep
Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation. [Abstract]2021 Sep 7;36(10):109659. PMID: 34496251 -
Cell Rep
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Research (Wash D C)
Metabolic Pathway of Monounsaturated Lipids Revealed by In-Depth Structural Lipidomics by Mass Spectrometry. [Abstract]2023:6:0087. PMID: 36951803 -
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Oncotarget
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer. [Abstract]2016 Oct 11;7(41):67071-67086. PMID: 27563814
Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Oct 11;7(41):67071-67086. [Abstract]
MDA-MB-453 cells are treated as indicated for 2 days and subjected to immunoblotting. Combination treatments using non-saturating doses of Etomoxir and MTI-31 or Rapamycin results in an enhanced growth suppression in MDA-MB-453 cells, which is not readily observed in MDA-MB-231 cells, correlating a nearly complete suppression of cyclin D1 and c-Myc level in MDA-MB-453 cells under the combination treatments.
Solvent & Solubility
DMSO : 50 mg/mL (155.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (15.59 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.79 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.79 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 3.33 mg/mL (10.38 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Roddy S O'Connor, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.Sci Rep. 2018 Apr 19;8(1):6289. [Content Brief]
[2]. Fred Y Xu,et al.Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.J Lipid Res. 2003 Feb;44(2):415-23. [Content Brief]
[3]. Jun Li, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus.Sci Rep. 2015 Jul 31;5:12724. [Content Brief]
[4]. Joost J F P Luiken, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.Biochem J. 2009 Apr 15;419(2):447-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1178 mL | 15.5890 mL | 31.1779 mL | 77.9448 mL |
| 5 mM | 0.6236 mL | 3.1178 mL | 6.2356 mL | 15.5890 mL | |
| 10 mM | 0.3118 mL | 1.5589 mL | 3.1178 mL | 7.7945 mL | |
| 15 mM | 0.2079 mL | 1.0393 mL | 2.0785 mL | 5.1963 mL | |
| DMSO | 20 mM | 0.1559 mL | 0.7794 mL | 1.5589 mL | 3.8972 mL |
| 25 mM | 0.1247 mL | 0.6236 mL | 1.2471 mL | 3.1178 mL | |
| 30 mM | 0.1039 mL | 0.5196 mL | 1.0393 mL | 2.5982 mL | |
| 40 mM | 0.0779 mL | 0.3897 mL | 0.7794 mL | 1.9486 mL | |
| 50 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5589 mL | |
| 60 mM | 0.0520 mL | 0.2598 mL | 0.5196 mL | 1.2991 mL | |
| 80 mM | 0.0390 mL | 0.1949 mL | 0.3897 mL | 0.9743 mL | |
| 100 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7794 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Etomoxir sodium salt Related Classifications
HY-50202A Related Classifications
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