1. Apoptosis
  2. Apoptosis
  3. Etomoxir sodium salt

Etomoxir sodium salt (Synonyms: (R)-(+)-Etomoxir sodium salt)

Cat. No.: HY-50202A Purity: 98.95%
Handling Instructions

Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

For research use only. We do not sell to patients.

Etomoxir sodium salt Chemical Structure

Etomoxir sodium salt Chemical Structure

CAS No. : 828934-41-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 504 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Etomoxir sodium salt:

Top Publications Citing Use of Products

    Etomoxir sodium salt purchased from MCE. Usage Cited in: Oncotarget. 2016 Oct 11;7(41):67071-67086.

    MDA-MB-453 cells are treated as indicated for 2 days and subjected to immunoblotting. Combination treatments using non-saturating doses of Etomoxir and MTI-31 or Rapamycin results in an enhanced growth suppression in MDA-MB-453 cells, which is not readily observed in MDA-MB-231 cells, correlating a nearly complete suppression of cyclin D1 and c-Myc level in MDA-MB-453 cells under the combination treatments.
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    Description

    Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

    IC50 & Target

    CPT-1a[2]

    Molecular Weight

    320.74

    Formula

    C₁₅H₁₈ClNaO₄

    CAS No.

    828934-41-4

    SMILES

    ClC1=CC=C(OCCCCCC[[email protected]@]2(CO2)C(O[Na])=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (311.78 mM; Need ultrasonic)

    H2O : 5 mg/mL (15.59 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1178 mL 15.5890 mL 31.1779 mL
    5 mM 0.6236 mL 3.1178 mL 6.2356 mL
    10 mM 0.3118 mL 1.5589 mL 3.1178 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (7.79 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.79 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.95%

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    Keywords:

    Etomoxir(R)-(+)-EtomoxirApoptosisirreversiblecarnitinepalmitoyltransferase1aCPT-1afattyacidoxidationFAOpalmitateβ-oxidationInhibitorinhibitorinhibit

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    Product Name:
    Etomoxir sodium salt
    Cat. No.:
    HY-50202A
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