Search Result

Results for "

1a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (14) Adenosine Receptor (5) Adrenergic Receptor (9) Aldehyde Dehydrogenase (ALDH) (10) Amyloid-β (2) Antibiotic (4) Apoptosis (15) Aurora Kinase (1) Autophagy (4) Bacterial (5) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcineurin (1) Calcium Channel (1) Cannabinoid Receptor (1) CDK (1) CRFR (1) DNA Methyltransferase (1) DNA/RNA Synthesis (4) Dopamine Receptor (7) Drug Metabolite (1) Dynamin (1) DYRK (11) EGFR (1) Endogenous Metabolite (3) Epigenetic Reader Domain (3) Fluorescent Dye (1) Fungal (2) GHSR (5) HBV (2) HCV (16) HCV Protease (4) HDAC (2) Histamine Receptor (3) Histone Demethylase (4) HIV (1) HSP (2) IFNAR (1) iGluR (2) Influenza Virus (1) Integrin (1) Isotope-Labeled Compounds (4) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) mGluR (2) MicroRNA (8) Necroptosis (1) Notch (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Oxytocin Receptor (2) p38 MAPK (1) Parasite (6) Phosphodiesterase (PDE) (1) Prostaglandin Receptor (2) PROTACs (2) Proteasome (1) Ras (3) Reactive Oxygen Species (2) SARS-CoV (8) Sigma Receptor (1) Sirtuin (1) Small Interfering RNA (siRNA) (160) Sodium Channel (13) STING (1) Thyroid Hormone Receptor (1) TMV (1) Topoisomerase (1) UGT (2) Vasopressin Receptor (3) VD/VDR (1) Virus Protease (1) γ-secretase (1)
By Research Areas:	Cancer (62) Cardiovascular Disease (6) Endocrinology (13) Infection (34) Inflammation/Immunology (16) Metabolic Disease (15) Neurological Disease (61)

By Targets:

5-HT Receptor (14)

Adenosine Receptor (5)

Adrenergic Receptor (9)

Aldehyde Dehydrogenase (ALDH) (10)

Amyloid-β (2)

Antibiotic (4)

Apoptosis (15)

Aurora Kinase (1)

Autophagy (4)

Bacterial (5)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Calcineurin (1)

Calcium Channel (1)

Cannabinoid Receptor (1)

CDK (1)

CRFR (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (4)

Dopamine Receptor (7)

Drug Metabolite (1)

Dynamin (1)

DYRK (11)

EGFR (1)

Endogenous Metabolite (3)

Epigenetic Reader Domain (3)

Fluorescent Dye (1)

Fungal (2)

GHSR (5)

HBV (2)

HCV (16)

HCV Protease (4)

HDAC (2)

Histamine Receptor (3)

Histone Demethylase (4)

HIV (1)

HSP (2)

IFNAR (1)

iGluR (2)

Influenza Virus (1)

Integrin (1)

Isotope-Labeled Compounds (4)

Ligands for E3 Ligase (1)

Ligands for Target Protein for PROTAC (2)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

mGluR (2)

MicroRNA (8)

Necroptosis (1)

Notch (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (1)

Oxytocin Receptor (2)

p38 MAPK (1)

Parasite (6)

Phosphodiesterase (PDE) (1)

Prostaglandin Receptor (2)

PROTACs (2)

Proteasome (1)

Ras (3)

Reactive Oxygen Species (2)

SARS-CoV (8)

Sigma Receptor (1)

Sirtuin (1)

Small Interfering RNA (siRNA) (160)

Sodium Channel (13)

STING (1)

Thyroid Hormone Receptor (1)

TMV (1)

Topoisomerase (1)

UGT (2)

Vasopressin Receptor (3)

VD/VDR (1)

Virus Protease (1)

γ-secretase (1)

By Research Areas:

Cancer (62)

Cardiovascular Disease (6)

Endocrinology (13)

Infection (34)

Inflammation/Immunology (16)

Metabolic Disease (15)

Neurological Disease (61)

349

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

462

Recombinant Proteins

Isotope-Labeled Compounds

131

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-104064

1A-116 5 Publications Verification	Ras Apoptosis	Cancer
1A-116, a potent *Rac1* inhibitor, is specific for W56 residues, can prevent EGF-induced *Rac1* activation and block *Rac1-P-Rex1* interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo ^[1] .

HY-W128112

1-(a-D-ribofuranosyl)uracil alpha-D-Ribofuranoside,2,4(1H,3H)-pyrimidinedione-1	Nucleoside Antimetabolite/Analog	Cancer
1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc ^[1].

HY-137584

1a,1b-Dihomo prostaglandin E1

1a,1b-Dihomo PGE1
Prostaglandin Receptor Endocrinology

1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound ^[1].

1a,1b-Dihomo prostaglandin E1 1a,1b-Dihomo PGE1	Prostaglandin Receptor	Endocrinology
1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound ^[1].

HY-131632

1a,1b-Dihomo prostaglandin F2α 1a,1b-Dihomo-PGF2α	Endogenous Metabolite	Others
1a,1b-Dihomo prostaglandin F2α (1a,1b-Dihomo-PGF2α) is the derivative of Prostaglandin F2α (HY-12956) ^[1].

HY-P3915

Esculentin 1A

Bacterial Infection

Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity ^[1].

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity ^[1].

HY-146483

Anti-Aβ agent 1A	Amyloid-β	Neurological Disease Inflammation/Immunology
Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H₂O₂ through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD) ^[1].

HY-50202A

Etomoxir sodium salt Maximum Cited Publications 63 Publications Verification (R)-(+)-Etomoxir sodium salt	Apoptosis	Metabolic Disease Cancer
Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig ^[1].

HY-108790

Peginterferon beta-1a Peginterferon β-1a	Apoptosis	Neurological Disease Cancer
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) ^[1].

HY-100431A

IMR-1A 1 Publications Verification	Notch Drug Metabolite	Cancer
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC₅₀ of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A ^[1].

HY-100840

(S)-4C3HPG (S)-4-Carboxy-3-hydroxyphenylglycine	mGluR	Neurological Disease
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice ^[1].

HY-P99138

Anti-Mouse IL-1a Antibody (ALF-161)

Integrin Inflammation/Immunology

Anti-Mouse IL-1a Antibody is an anti-mouse IL-1a IgG1 antibody inhibitor derived from host Armenian Hamster.
HY-136267

HCV-IN-30

HCV Infection

HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC₅₀s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively ^[1].
HY-136972

(-)-GB-1a

(-)-Biflavanone GB-1a
Others Others

(-)-GB-1a is a potent antioxidant agent with an IC₅₀ value of 148 µM ^[1].

Anti-Mouse IL-1a Antibody (ALF-161)	Integrin	Inflammation/Immunology
Anti-Mouse IL-1a Antibody is an anti-mouse IL-1a IgG1 antibody inhibitor derived from host Armenian Hamster.

HCV-IN-30	HCV	Infection
HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC₅₀s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively ^[1].

(-)-GB-1a (-)-Biflavanone GB-1a	Others	Others
(-)-GB-1a is a potent antioxidant agent with an IC₅₀ value of 148 µM ^[1].

HY-A0084A

Procainamide 3 Publications Verification Procaine amide; SP 100	DNA Methyltransferase	Cardiovascular Disease Cancer
Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias ^[1] .

HY-136532

ZT-1a	Others	Neurological Disease
ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC₅₀s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively ^[1].

HY-118335

Prazobind SZL 49	Adrenergic Receptor	Neurological Disease
Prazobind (SZL 49), a prazosin analog, is a potent alpha 1-adrenoceptor blocker. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀=1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes ^[1] .

HY-P99861

Peginterferon lambda-1a

BMS-914143
IFNAR Others

Peginterferon lambda-1a (BMS-914143) is a monoclonal antibody targeting IFNLR1 and consists of IFNL1 conjugated to pegol ^[1].

Peginterferon lambda-1a BMS-914143	IFNAR	Others
Peginterferon lambda-1a (BMS-914143) is a monoclonal antibody targeting IFNLR1 and consists of IFNL1 conjugated to pegol ^[1].

HY-50202

Etomoxir Maximum Cited Publications 63 Publications Verification (R)-(+)-Etomoxir	Apoptosis	Metabolic Disease Cancer
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-131994

STING agonist-16	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool ^[1].

HY-R02806

mmu-miR-1a-1-5p mimic	MicroRNA	Cancer
mmu-miR-1a-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-1a-1-5p mimic mmu-miR-1a-1-5p mimic

HY-R02807

mmu-miR-1a-2-5p mimic	MicroRNA	Cancer
mmu-miR-1a-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-1a-2-5p mimic mmu-miR-1a-2-5p mimic

HY-12294A

PEAQX tetrasodium hydrate 5 Publications Verification NVP-AAM077 tetrasodium hydrate	iGluR Apoptosis	Neurological Disease
PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC₅₀ values of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively ^[1].

HY-12294

PEAQX NVP-AAM077	iGluR	Neurological Disease
PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).

HY-15522

WAY-267464	Oxytocin Receptor	Neurological Disease
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder ^[1].

HY-157448

CBR1-IN-6

Apoptosis Cancer

CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities ^[1].

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a *CBR1* inhibitor with chemosensitizing and cardioprotective activities ^[1].

HY-RI02806

mmu-miR-1a-1-5p inhibitor	MicroRNA
mmu-miR-1a-1-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-1a-1-5p inhibitor mmu-miR-1a-1-5p inhibitor

HY-RI02807

mmu-miR-1a-2-5p inhibitor	MicroRNA
mmu-miR-1a-2-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-1a-2-5p inhibitor mmu-miR-1a-2-5p inhibitor

HY-U00433

JMV 2959

2 Publications Verification

GHSR Neurological Disease Endocrinology

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

JMV 2959 2 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

HY-149694

Aurora kinase inhibitor-12	Aurora Kinase	Cancer
Aurora Kinase Inhibitor-12 (Compound 1a ) is the inhibitor of aurora kinase which is a key enzyme that is implicated in tumor growth ^[1].

HY-112078

(S,R,S)-AHPC-Me VHL ligand 2; E3 ligase Ligand 1a	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein ^[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM .

HY-12782T

Iadademstat dihydrochloride 3 Publications Verification ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride	Histone Demethylase	Cancer
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

HY-115938

BEC2

Others Metabolic Disease

BEC2 is an ester derivative of Baicalin, with good lipid-lowering activity. BEC2 can direct activate the carnitine palmitoyltransferase 1A (CPT1A) ^[1].

BEC2	Others	Metabolic Disease
BEC2 is an ester derivative of Baicalin, with good lipid-lowering activity. BEC2 can direct activate the carnitine palmitoyltransferase 1A (CPT1A) ^[1].

HY-115995

Antitumor agent-50	Others	Cancer
Antitumor agent-50 (compound 1a), a thiazolidinone, is a potent antitumor agent. Antitumor agent-50 has the potential for osteosarcoma (OS) research ^[1].

HY-150074

STING agonist-18

Others Cancer

STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate ^[1].

STING agonist-18	Others	Cancer
STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate ^[1].

HY-147060

Dyrk1A-IN-3	DYRK	Neurological Disease
Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC₅₀=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease ^[1].

HY-19612B

DDP-38003 trihydrochloride	Histone Demethylase	Cancer
DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM.

HY-12981

RG7713 2 Publications Verification RO5028442	Vasopressin Receptor	Neurological Disease Endocrinology
RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with K_is of 1 nM (hV1a) and 39 nM (mV1a).

HY-U00433A

JMV 2959 hydrochloride 2 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-19612A

DDP-38003 dihydrochloride

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM ^[1].

DDP-38003 dihydrochloride
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM ^[1].

HY-D1453

Immune initiator-1	Biochemical Assay Reagents	Cancer
Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma ^[1].

HY-12731

GSK2236805

HCV Infection

GSK2236805 is a potent hepatitis C virus inhibitor with pEC₅₀ values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively ^[1].

GSK2236805	HCV	Infection
GSK2236805 is a potent hepatitis C virus inhibitor with pEC₅₀ values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively ^[1].

HY-110001

(S)-WAY 100135 dihydrochloride	5-HT Receptor	Neurological Disease
(S)-WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT _1A (IC₅₀=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models ^[1].

HY-R02806A

mmu-miR-1a-1-5p agomir	MicroRNA
mmu-miR-1a-1-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-1a-1-5p agomir mmu-miR-1a-1-5p agomir

HY-R02807A

mmu-miR-1a-2-5p agomir	MicroRNA
mmu-miR-1a-2-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-1a-2-5p agomir mmu-miR-1a-2-5p agomir

HY-162108

Antitumor agent-128	Apoptosis	Cancer
Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells ^[1].

HY-15789

Elbasvir 5+ Cited Publications MK-8742	HCV	Infection
Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC₅₀s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

HY-109024

Balovaptan RG7314	Vasopressin Receptor	Neurological Disease Endocrinology
Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with K_is of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

HY-153637

THR-β modulator-1	Thyroid Hormone Receptor	Endocrinology
THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders ^[1].

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction ^[1].

HY-11100

Asenapine maleate 1 Publications Verification Org 5222 maleate	5-HT Receptor	Neurological Disease
Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with K_i values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.

Cat. No.	Product Name	Target	Research Area

HY-N11615

Cyclo(Pro-Val)

Peptides Others

Cyclo(Pro-Val) can be isolated from Pseudomonas fluorescens GcM5-1A and has cytotoxicity ^[1].
HY-P3915

Esculentin 1A

Bacterial Infection

Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity ^[1].

HY-P5176

Latartoxin-1a LtTx-1a	Peptides	Neurological Disease
Latartoxin-1a (LtTx-1a) is a peptide toxin can be isolated from L. tarabaevi. Latartoxin-1a is paralytic and lethal to insects and has membrane-bound activity ^[1].

HY-P1610

Asudemotide	Peptides	Cancer
Asudemotide (S-588410) is a peptide of human DEP domain-containing protein 1A. Asudemotide is an immunostimulant. Asudemotide has a sequence of H-Glu-Tyr-Tyr-Glu-Leu-Phe-Val-Asn-Ile-OH. Asudemotide induces a tumor immune response in esophageal cancer. ^[1].

HY-P5780

π-TRTX-Hm3a	Sodium Channel	Neurological Disease
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC₅₀ of 1-2 nM and potentiates *ASIC1b* with an EC₅₀ of 46.5 nM ^[1].

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for *GHS-1a* receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research ^[1] .

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for *GHS-1a* receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research ^[1] .

HY-P4542

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)	CRFR	Endocrinology
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition ^[1].

HY-P1411

Psalmotoxin 1 1 Publications Verification PcTx1; Psalmopoeus cambridgei toxin-1	Sodium Channel Apoptosis	Neurological Disease Cancer
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease ^[1] .

HY-P5865

Tap1a Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a	Sodium Channel	Neurological Disease
Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC₅₀s of 80 nM and 301 nM against Na_v1.7 and Na_v1.1, respectively. Tap1a shows analgesic effects ^[1].

HY-P5813

Cd1a β-TRTX-cd1a; β-Theraphotoxin-cd1a	Peptides	Neurological Disease
Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Ca_v2.2)(IC₅₀2.6 μM) and mouse sodium ion channels (Na_v1.7). Cd1a can be used in the development of peripheral pain treatment drugs ^[1].

HY-P5801

Phlo1a μ-TrTx-Phlo1a	Sodium Channel	Neurological Disease
Phlo1a (μ-TrTx-Phlo1a) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective *Nav1.7* inhibitor. Phlo1a has a weak inhibitory effect on Nav1.2 and Nav1.5 ^[1].

HY-P5162

Dc1a	Sodium Channel	Inflammation/Immunology
Dc1a potently promotes opening of the German cockroach Na_v channel (BgNa_v1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities ^[1].

HY-P5183

Hm1a	Sodium Channel	Neurological Disease
Hm1a is a disulfide-rich spider-venom peptide, and a *NaV1.1* activator. Hm1a restores the function of inhibitory interneurons in Dravet syndrome (DS) mouse model ^[1].

HY-P5637

Tur1A	Bacterial	Infection
Tur1A is an antimicrobial peptide derived from bottlenose dolphins Tursiops truncates. Tur1A inhibits bacterial protein synthesis by binding to ribosomes and blocking the transition from the initiation stage to the extension stage ^[1].

HY-P2265

SAH-SOS1A	Ras	Cancer
SAH-SOS1A is a peptide-based *SOS1/KRAS* protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS ^[1].

HY-P2265A

SAH-SOS1A TFA	Ras	Cancer
SAH-SOS1A TFA is a peptide-based *SOS1/KRAS* protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS ^[1].

HY-P3058

Ederimotide

WT-1 A1
Peptides Cancer

Ederimotide(WT-1 A1) can be used as a potential target for studying pancreatic cancer ^[1].

HY-P5790

μ-TRTX-Hd1a	Sodium Channel	Neurological Disease
μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II ^[1].

HY-P5784

δ-Buthitoxin-Hj1a	Sodium Channel	Neurological Disease
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, is a potent *NaV1.1* agonist with an EC₅₀ of 17nM. δ-Buthitoxin-Hj1a can be used for the Dravet syndrome (DS) research ^[1].

HY-P1355

Cyclosporin A-Derivative 1	Calcineurin	Inflammation/Immunology
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P5782

δ-Theraphotoxin-Hm1a toxin	Sodium Channel	Neurological Disease
δ-Theraphotoxin-Hm1a toxin is a selective *Na_v1.1* activator. δ-Theraphotoxin-Hm1a toxin elicits pain and touch sensitivity. δ-Theraphotoxin-Hm1a toxin can be used for the research of irritable bowel syndrome ^[1].

HY-P5153

ProTx-III μ-TRTX-Tp1a	Sodium Channel	Neurological Disease
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel *Na_v1.7, with an IC₅₀* of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia ^[1].

HY-P5811

Ceratotoxin-1 CcoTx1; β-TRTX-cm1a	Sodium Channel	Neurological Disease
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits *Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1* with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits *Nav1.8/β1* ^[1].

HY-P5142

ω-Hexatoxin-Hv1a ω-ACTX-Hv1; ω-Atracotoxin-HV1	Calcium Channel	Neurological Disease
ω-Hexatoxin-Hv1a is a neurotoxin that can be isolated from the venom spider (Hadronyche versuta).ω-Hexatoxin-Hv1a blocks voltage-gated calcium channels ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11615

Cyclo(Pro-Val)	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Others
Cyclo(Pro-Val) can be isolated from Pseudomonas fluorescens GcM5-1A and has cytotoxicity ^[1].

HY-B1167

Ajmaline Cardiorythmine; (+)-Ajmaline	Apocynaceae Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Rauvolfia serpentina Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids	Sodium Channel
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC₅₀ of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia ^[1] .

HY-N6615

Aflatoxin B1 2 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Parasite
Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation ^[1] .

HY-136972

(-)-GB-1a (-)-Biflavanone GB-1a	Garcinia prainiana King Structural Classification Flavonoids Flavonones Source classification Guttiferae Plants	Others
(-)-GB-1a is a potent antioxidant agent with an IC₅₀ value of 148 µM ^[1].

HY-N6615R

Aflatoxin B1 (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenylpropanoids Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Parasite
Aflatoxin B1 (Standard) is the analytical standard of Aflatoxin B1. This product is intended for research and analytical applications. Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation ^[1] .

HY-19828

Herboxidiene GEX1a	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	DNA/RNA Synthesis
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome ^[1] .

HY-N10985

Xanthone V1a	Structural Classification Flavonoids Maclura fruticosa (Roxburgh) Corner Source classification Plants Moraceae Other Flavonoids	Others
Xanthone V1a has antioxidant activity against the DPPH radical (IC₅₀: 10.43 µM). Xanthone V1a has cytotoxicity against cancer cells ^[1] .

HY-N10511

GM1a Ganglioside oligosaccharide	Structural Classification Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses ^[1].

HY-123686

Ivermectin B1a monosaccharide	Structural Classification Natural Products Microorganisms Source classification	Parasite
Ivermectin B1a monosaccharide is a modified Ivermectin B1a (HY-126937). Ivermectin B1a monosaccharide is an antiparasite agent with a minimum concentration for full activity in Haemonchus contortus larval development of 0.001 μg/mL ^[1].

HY-15311

Avermectin B1 4 Publications Verification Abamectin; Avermectin B1a-Avermectin B1b mixt.	Structural Classification Classification of Application Fields Source classification Anti-parasitic Antibacterial Disease Research Biological Pesticide Research Agricultural Research Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Inflammation/Immunology Disease Research Fields	Parasite Autophagy Apoptosis Reactive Oxygen Species Antibiotic
Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-15602S

Ledipasvir-d6
Ledipasvir-d₆ is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

HY-A0077S1

Perphenazine-d4
Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-16567S

Asenapine-13C,d3 hydrochloride
Asenapine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-N6615S

Aflatoxin B1-13C17
Aflatoxin B1- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation ^[1] .

HY-113459S

Prostaglandin F1a-d9

Prostaglandin F1a-d₉ is the deuterium labeled Prostaglandin F1a[1].

HY-137083S

Trifluoperazine N-glucuronide-d3
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].

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