1. Metabolic Enzyme/Protease
    Anti-infection
  2. HCV Protease
    HCV
  3. Paritaprevir

Paritaprevir (Synonyms: ABT-450; Veruprevir)

Cat. No.: HY-12594 Purity: 99.85%
Handling Instructions

Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.

For research use only. We do not sell to patients.

Paritaprevir Chemical Structure

Paritaprevir Chemical Structure

CAS No. : 1216941-48-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 192 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 228 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1128 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 9 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.

IC50 & Target

EC50: 1 nM(HCV 1a), 0.21 nM(HCV 1b)[1]

In Vitro

Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

765.88

Formula

C₄₀H₄₃N₇O₇S

CAS No.

1216941-48-8

SMILES

O=C([[email protected]]1(NC([[email protected]@]2([H])N3C[[email protected]](OC4=C(C=CC=C5)C5=C6C(C=CC=C6)=N4)C2)=O)[[email protected]](/C=C\CCCCC[[email protected]](NC(C7=NC=C(C)N=C7)=O)C3=O)C1)NS(=O)(C8CC8)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (163.21 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3057 mL 6.5284 mL 13.0569 mL
5 mM 0.2611 mL 1.3057 mL 2.6114 mL
10 mM 0.1306 mL 0.6528 mL 1.3057 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.85%

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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ParitaprevirABT-450 VeruprevirABT450ABT 450HCV ProteaseHCVHepatitis C virusInhibitorinhibitorinhibit

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Product Name:
Paritaprevir
Cat. No.:
HY-12594
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