1. Anti-infection
  2. HCV

Paritaprevir (Synonyms: ABT-450; Veruprevir)

Cat. No.: HY-12594 Purity: >98.0%
Data Sheet SDS Handling Instructions

Paritaprevir is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.

For research use only. We do not sell to patients.
Paritaprevir Chemical Structure

Paritaprevir Chemical Structure

CAS No. : 1216941-48-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $160 In-stock
5 mg $150 In-stock
10 mg $190 In-stock
50 mg $550 In-stock
100 mg $940 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Paritaprevir is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.

IC50 & Target

EC50: 1 nM(HCV 1a), 0.21 nM(HCV 1b)[1]

In Vitro

Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].

In Vivo

The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.3057 mL 6.5284 mL 13.0569 mL
5 mM 0.2611 mL 1.3057 mL 2.6114 mL
10 mM 0.1306 mL 0.6528 mL 1.3057 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

765.88

Formula

C₄₀H₄₃N₇O₇S

CAS No.

1216941-48-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Paritaprevir
Cat. No.:
HY-12594
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