1. Metabolic Enzyme/Protease
    Anti-infection
  2. HCV Protease
    HCV
    SARS-CoV
  3. Paritaprevir

Paritaprevir  (Synonyms: ABT-450; Veruprevir)

Cat. No.: HY-12594 Purity: 99.89%
COA Handling Instructions

Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor).

For research use only. We do not sell to patients.

Paritaprevir Chemical Structure

Paritaprevir Chemical Structure

CAS No. : 1216941-48-8

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10 mM * 1 mL in DMSO USD 192 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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10 mg USD 228 In-stock
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50 mg USD 660 In-stock
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100 mg USD 1128 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

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Description

Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor)[1][2][3][4].

IC50 & Target

EC50: 1 nM (HCV 1a), 0.21 nM (HCV 1b)[1]
IC50: 1.31 μM (SARS-CoV 3CLpro)[3]

In Vitro

Paritaprevir has in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The combination of Paritaprevir, Ritonavir, Ombitasvir (an NS5A protein inhibitor), and Dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections[1][4].
The acute toxicity of Paritaprevir is considered to be low. Single oral doses of ≤600 mg/kg in rats and ≤100 mg/kg in dogs produces no mortality and were well tolerated. However, since Paritaprevir is administered without ritonavir as a PK enhancer, the exposures are low, especially in male rats (rat 600 mg/kg, males: Cmax 1.82 μg/mL, AUC0-24 8.89 μg·h/mL; dog 100 mg/kg, mean: Cmax 61.3 μg/mL, AUC0-24 285 μg·h/mL).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

765.88

Formula

C40H43N7O7S

CAS No.
SMILES

O=C([[email protected]]1(NC([[email protected]@]2([H])N3C[[email protected]](OC4=C(C=CC=C5)C5=C6C(C=CC=C6)=N4)C2)=O)[[email protected]](/C=C\CCCCC[[email protected]](NC(C7=NC=C(C)N=C7)=O)C3=O)C1)NS(=O)(C8CC8)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (163.21 mM)

H2O : ≥ 0.1 mg/mL (0.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3057 mL 6.5284 mL 13.0569 mL
5 mM 0.2611 mL 1.3057 mL 2.6114 mL
10 mM 0.1306 mL 0.6528 mL 1.3057 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.72 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.89%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Paritaprevir
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