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Ritonavir

(Synonyms: ABT 538; RTV)
33 Cited Publications
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Based on 33 publication(s) in Google Scholar

Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM. Ritonavir (ABT 538) can penetrate the blood brain barrier (BBB).

For research use only. We do not sell to patients.

  • Purity: 99.96%
  • CAS No.: 155213-67-5
  • Formula: C37H48N6O5S2
  • Molecular Weight:720.94
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Ritonavir Chemical Structure
    Ritonavir Chemical Structure
  • Experimental Validation Results for Ritonavir
  • Experimental Validation Results for Ritonavir
  • Experimental Validation Results for Ritonavir
  • Experimental Validation Results for Ritonavir
  • Experimental Validation Results for Ritonavir
CAS No.: 155213-67-5
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  • Ritonavir Chemical Structure
    Ritonavir Chemical Structure
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    Ritonavir purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jun 3;13(1):58. [Abstract]

    Customer Validation
     Lopinavir (100 or 200 mg/kg)/ritonavir (25 or 50 mg/kg) i.p., every 2 days for 28 days) aggravated osteophyte formation in the DMM model.

  • 1/16

    Ritonavir purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jun 3;13(1):58. [Abstract]

    Customer Validation
     Lopinavir (100 or 200 mg/kg)/ritonavir (25 or 50 mg/kg, i.p., every 2 days for 28 days) aggravated cartilage erosion and synovitis in the DMM model.

  • 1/16

    Ritonavir purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jun 3;13(1):58. [Abstract]

    Customer Validation
     Lopinavir (100 or 200 mg/kg)/ritonavir (25 or 50 mg/kg, i.p., every 2 days for 28 days) decreased the proportion of Sox9-positive cells from 36% to 18% and increased the proportion of p21-positive cells from 32% to 60%.

  • 1/16

    Ritonavir purchased from MedChemExpress. Usage Cited in: SLAS Discov. 2025 Mar:31:100211. [Abstract]

    Customer Validation
     Susceptibility of icSARS-CoV-2-nLuc to ritonavir was assessed using luminescence signal readout. C3 cells were seeded in 384-well plates and treated with ritonavir 2 h before infection using three-fold serial dilutions ranging from 36 µM to 0.005 µM, with two technical replicates per concentration. The cells were infected with icSARS-CoV-2-nLuc at an MOI of 0.05 and incubated for 24 h at 37 °C with 5% CO₂. The next day, nLuc activity was measured, and the data were analyzed using GraphPad Prism software to obtain IC₅₀ curves. The graph represents the results of two independent experiments.

  • 1/16

    Ritonavir purchased from MedChemExpress. Usage Cited in: Vet Sci. 2023 Aug 9;10(8):513. [Abstract]

    Customer Validation
     The CC50, EC50, and SI for six compounds against FIPV. The half-maximal cytotoxic concentration (CC50) values are from four measurements of diluted drugs using MTT assay, in CRFK cells treated with drugs for 48 h. The half-maximal effective concentration (EC50) values are from six measurements of diluted drugs against FIPV replication in CRFK cells for 48 h. Based on the SI value (mean CC50)/(mean EC50), GS-441524 was found highly selective (SI 165.5) against FIPV among the drugs tested and showed high efficacy (EC50 1.6 µM) against FIPV with a less deleterious effect (CC50 260.0 µM) on the cells. Nirmatrelvir also showed promising efficacy (EC50 2.5 µM) and selectivity (SI 113.7) against FIPV. Ritonavir showed the highest toxicity level in the cells (CC50 39.9).

  • Ritonavir