1. Metabolic Enzyme/Protease
    Anti-infection
  2. HIV Protease
    HIV
  3. Ritonavir

Ritonavir (Synonyms: ABT 538; RTV)

Cat. No.: HY-90001 Purity: 99.68%
Handling Instructions

Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS.

For research use only. We do not sell to patients.

Ritonavir Chemical Structure

Ritonavir Chemical Structure

CAS No. : 155213-67-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg USD 180 In-stock
Estimated Time of Arrival: December 31
500 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Description

Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS.

In Vitro

Ritonavir (ABT 538) is an inhibitor of CYP3A4 mediated testosterone 6β-hydroxylation with mean Ki of 19 nM and also inhibits tolbutamide hydroxylation with IC50 of 4.2 μM[1]. Ritonavir (ABT 538) is found to be a potent inhibitor of CYP3A-mediated biotransformations (nifedipine oxidation with IC50 of 0.07 mM, 17alpha-ethynylestradiol 2-hydroxylation with IC50 of 2 mM; terfenadine hydroxylation with IC50 of 0.14 mM). Ritonavir is also an inhibitor of the reactions mediated by CYP2D6 (IC50=2.5 mM) and CYP2C9/10 (IC50=8.0 mM)[2]. Ritonavir results in an increase in cell viability in uninfected human PBMC cultures. Ritonavir markedly decreases the susceptibility of PBMCs to apoptosis correlated with lower levels of caspase-1 expression, decreases in annexin V staining, and reduces caspase-3 activity in uninfected human PBMC cultures. Ritonavir inhibits induction of tumor necrosis factor (TNF) production by PBMCs and monocytes in a time- and dose-dependent manner at nontoxic concentrations[3]. Ritonavir inhibits p-glycoprotein-mediated extrusion of saquinavir with an IC50 of 0.2 μM, indicating a high affinity of ritonavir for p-glycoprotein[4]. Ritonavir inhibits human liver microsomal metabolism of ABT-378 potently with Ki of 13 nM. Ritonavir combined with ABT-378 (at 3:1 and 29:1 ratios) inhibits CYP3A (IC50=1.1 and 4.6 μM), albeit less potently than Ritonavir (IC50=0.14 μM)[5].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (34.68 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3871 mL 6.9354 mL 13.8708 mL
5 mM 0.2774 mL 1.3871 mL 2.7742 mL
10 mM 0.1387 mL 0.6935 mL 1.3871 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (3.47 mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.
References
Molecular Weight

720.94

Formula

C₃₇H₄₈N₆O₅S₂

CAS No.

155213-67-5

SMILES

O=C(N[[email protected]@H](CC1=CC=CC=C1)[[email protected]](C[[email protected]](CC2=CC=CC=C2)NC([[email protected]](C(C)C)NC(N(CC3=CSC(C(C)C)=N3)C)=O)=O)O)OCC4=CN=CS4

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.68%

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Product Name:
Ritonavir
Cat. No.:
HY-90001
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Ritonavir

Cat. No.: HY-90001