Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease

Signal Transduct Target Ther. 2021 May 29;6(1):212. doi: 10.1038/s41392-021-00628-x.

Qi Sun ^# ¹, Fei Ye ^# ², Hao Liang ^# ¹, Hongbo Liu ^# ¹, Chunmei Li ³, Roujian Lu ², Baoying Huang ², Li Zhao ², Wenjie Tan ⁴, Luhua Lai ⁵ ⁶

Affiliations

1 BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
2 NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China.
3 Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
4 NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China. [email protected].
5 BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China. [email protected].
6 Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [email protected].
# Contributed equally.

PMID: 34052830 DOI: 10.1038/s41392-021-00628-x

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-90001

Ritonavir

99.92%, HIV Protease Inhibitor

HIV Protease; HIV; SARS-CoV; Apoptosis

Infection; Cancer
HY-14434

Asunaprevir

99.71%, HCV Protease Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-15298

Grazoprevir

99.99%, HCV Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-14909

Bardoxolone

99.14%, Keap1-Nrf2 Activator

Keap1-Nrf2; Necroptosis

Metabolic Disease
HY-10241

Simeprevir

99.90%, HCV NS3/4A Inhibitor

HCV; HCV Protease; SARS-CoV; DNA/RNA Synthesis

Infection
HY-14588

Lopinavir

99.93%, HIV-1 Protease Inhibitor

HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-15287

Nelfinavir

98.83%, HIV Protease Inhibitor

HIV Protease; HIV

Infection; Cancer
HY-17007

Saquinavir

99.73%, HIV Protease Inhibitor

HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-17634

Glecaprevir

99.93%, HCV NS3/4A Protease Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-15602

Ledipasvir

99.68%, HCV NS5A Inhibitor

HCV; SARS-CoV

Infection
HY-B0689A

Indinavir sulfate

99.96%, HIV Protease Inhibitor

HIV; HIV Protease; SARS-CoV; Apoptosis; MMP

Infection; Cancer
HY-10237

Boceprevir

98.79%, HCV NS3 Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-12594

Paritaprevir

99.89%, NS3/4A Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-10235

Telaprevir

99.54%, HCV NS3-4A Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-17040

Darunavir

99.84%, HIV Protease Inhibitor

HIV; HIV Protease

Inflammation/Immunology; Infection
HY-12530

Velpatasvir

99.26%, HCV NS5A Inhibitor

HCV; SARS-CoV

Inflammation/Immunology; Infection; Cancer
HY-10238

Danoprevir

99.69%, HCV NS3/4A Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-15148

Tipranavir

98.08%, HIV Protease Inhibitor

HIV Protease; HIV; SARS-CoV

Infection
HY-15287A

Nelfinavir Mesylate

98.93%, HIV-1 Protease Inhibitor

HIV Protease; HIV

Infection; Cancer
HY-17367A

Atazanavir sulfate

99.94%, HIV Protease Inhibitor

HIV; HIV Protease; SARS-CoV; Cytochrome P450; P-glycoprotein; Endogenous Metabolite

Infection; Cancer
HY-15298A

Grazoprevir potassium salt

99.63%, HCV Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-17430

Amprenavir

99.58%, HIV Protease Inhibitor

HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-10300

Narlaprevir

98.15%, NS3 Protease Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-17367

Atazanavir

99.23%, HIV Protease Inhibitor

HIV; HIV Protease; SARS-CoV; Cytochrome P450; P-glycoprotein; Endogenous Metabolite

Infection; Cancer
HY-15298B

Grazoprevir hydrate

99.99%, HCV Protease Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-12594A

Paritaprevir dihydrate

NS3/4A Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-17430S

Amprenavir-d₄

Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-17367S3

Atazanavir-d₅

Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV; Cytochrome P450; P-glycoprotein; Endogenous Metabolite

Infection; Cancer
HY-17367S2

Atazanavir-d₉

Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV; Cytochrome P450; P-glycoprotein; Endogenous Metabolite

Infection; Cancer
HY-10237S

Boceprevir-d₉

Stable Isotope

Isotope-Labeled Compounds; HCV Protease; HCV; SARS-CoV

Infection
HY-90001S1

Ritonavir-¹³C,d₃

Stable Isotope

HIV Protease; HIV; SARS-CoV; Apoptosis

Infection
HY-17007S

Saquinavir-d₉

Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-15602S

Ledipasvir-d₆

≥99.0%, Stable Isotope

HCV; SARS-CoV

Infection
HY-90001S

Ritonavir-d₆

98.84%, Stable Isotope

HIV Protease; HIV; SARS-CoV; Apoptosis

Infection
HY-10235S

Telaprevir-d₄

Stable Isotope

Isotope-Labeled Compounds; HCV Protease; HCV; SARS-CoV

Infection
HY-17367S4

Atazanavir-d₆

99.28%, Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV; Cytochrome P450; P-glycoprotein; Endogenous Metabolite

Infection; Cancer
HY-17430S1

Amprenavir-d₄-1

Stable Isotope

Isotope-Labeled Compounds; HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-15602C

Ledipasvir hydrochloride

HCV NS5A Inhibitor

HCV; SARS-CoV

Infection
HY-14588R

Lopinavir (Standard)

HIV-1 Protease Inhibitor

HIV; HIV Protease; SARS-CoV

Infection; Cancer
HY-90001R

Ritonavir (Standard)

HIV Protease Inhibitor

HIV Protease; HIV; SARS-CoV; Apoptosis

Infection; Cancer
HY-15298C

Grazoprevir sodium salt

HCV Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-14588S1

Lopinavir-d₈

Stable Isotope

HIV; HIV Protease; SARS-CoV

Infection
HY-15287S

Nelfinavir-d₃

Stable Isotope

Isotope-Labeled Compounds; HIV Protease; HIV

Infection; Cancer

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