2. Anti-infection Metabolic Enzyme/Protease
  3. HCV HCV Protease SARS-CoV
  4. Grazoprevir sodium salt

Grazoprevir sodium salt  (Synonyms: MK-5172 sodium salt)

Cat. No.: HY-15298C
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Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir sodium salt inhibits SARS-CoV-2 3CLpro activity.

For research use only. We do not sell to patients.

CAS No. : 1425038-27-2

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Grazoprevir sodium salt Related Antibodies

Top Publications Citing Use of Products

29 Publications Citing Use of MCE Grazoprevir sodium salt

ELISA
Cell Proliferation/Viability Assay
In Vivo Imaging
In Vivo Efficacy Study

    Grazoprevir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2022 Nov 14;40(11):1294-1305.e4.  [Abstract]

    Primary T cell lines were treated with or without Grazoprevir (all in the presence of target cells), and cytokine levels quantified.

    Grazoprevir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2022 Nov 14;40(11):1294-1305.e4.  [Abstract]

    Cytotoxicity response of OFF VIPER CAR T cells to Grazoprevir being added, washed out, and re-introduced after two days.

    Grazoprevir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2022 Nov 14;40(11):1294-1305.e4.  [Abstract]

    Grazoprevir dose-response profile of various cells, as measured in cytokine levels and cell killing.

    Grazoprevir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2022 Nov 14;40(11):1294-1305.e4.  [Abstract]

    IVIS imaging of groups treated with (1) no T cells, (2) non-transduced T cell (NT-WT), (3) ON VIPER CAR T cells, (4) ON VIPER CAR T cells with Grazoprevir (5) OFF VIPER CAR T cells, (6) OFF VIPER CAR T cells with Grazoprevir, or (7) Traditional CAR T cells by day 21.

    Grazoprevir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2022 Nov 14;40(11):1294-1305.e4.  [Abstract]

    Illustration of the dual-tumor model generated by systemically growing Nalm6 cells via i.v. and regional growth of MSTO-211H cells via s.c (left). Timeline for the in vivo experiment (right). Inducers (Grazoprevir or POM) were injected daily through i.p.

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    Description

    Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir sodium salt inhibits SARS-CoV-2 3CLpro activity[3].

    Molecular Weight

    788.89

    Formula

    C38H49N6NaO9S
    CAS No.
    SMILES

    COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C([N-]S(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1.[Na+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Grazoprevir sodium salt Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Grazoprevir1425038-27-2MK-5172MK5172MK 5172HCVHCV ProteaseSARS-CoVHepatitis C virusSARS coronavirusInhibitorinhibitorinhibit

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