1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease
  3. Glecaprevir

Glecaprevir (Synonyms: ABT-493)

Cat. No.: HY-17634 Purity: 99.65%
Handling Instructions

Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.

For research use only. We do not sell to patients.

Glecaprevir Chemical Structure

Glecaprevir Chemical Structure

CAS No. : 1365970-03-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 609 In-stock
Estimated Time of Arrival: December 31
2 mg USD 228 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2220 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

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Description

Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.

IC50 & Target

IC50: 3.5~11.3 nM (HCV NS3/4A protease)[1]

In Vitro

Glecaprevir inhibits the enzymatic activity of HCV genotype 1-6 NS3/4A proteases with half maximal inhibitory concentration (IC50) values ranging from 3.5 to 11.3 nM in a biochemical assay. Glecaprevir inhibites HCV subgenomic stable replicons containing proteases from HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a and 6e in Huh-7 cells with 50% effective concentration (EC50) values ranging from 0.21 to 4.6 nM. Glecaprevir is active against a replicon containing protease from genotype 3, the most difficult-to-treat HCV genotype, with an EC50 value of 1.9 nM, which is 10- and 44-fold lower than those for paritaprevir and grazoprevir, respectively. The median Glecaprevir EC50 values against replicons containing these genotype 1a, 1b, 2a, 2b, 3a, 4a, 4d, and 5a clinical samples are 0.08, 0.29, 1.6, 2.2, 2.3, 0.41, 0.17, and 0.12 nM, respectively, with an overall median EC50 value of 0.30 nM (range=0.05~3.8 nM)[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (99.30 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1921 mL 5.9604 mL 11.9208 mL
5 mM 0.2384 mL 1.1921 mL 2.3842 mL
10 mM 0.1192 mL 0.5960 mL 1.1921 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

The activity of Glecaprevir, paritaprevir or grazoprevir is determined against nine cell lines each stably transfected with an HCV subgenomic replicon containing NS3 protease from a different HCV genotype using a luciferase reporter assay as described previously. All replicon constructs are bicistronic subgenomic replicons, and the replicon cell lines are generated by introducing these constructs into a Huh-7 human hepatoma-derived cell line. The inhibitory effect of Glecaprevir on HCV replication in replicon cells is determined in Dulbecco's modified eagle medium containing 5% fetal bovine serum with or without 40% human plasma. The EC50 values are determined using nonlinear regression curve[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

838.87

Formula

C₃₈H₄₆F₄N₆O₉S

CAS No.

1365970-03-1

SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(O[[email protected]@]2([H])[[email protected]@]3([H])CCC2)=O)C(C)(C)C)=O)C[[email protected]@](OC4=NC5=CC=CC=C5N=C4C(F)(/C=C/CO3)F)([H])C1)N[[email protected]]6([[email protected]](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Glecaprevir
Cat. No.:
HY-17634
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Glecaprevir

Cat. No.: HY-17634