1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
  3. Saquinavir

Saquinavir (Synonyms: Ro 31-8959)

Cat. No.: HY-17007 Purity: 99.91%
Handling Instructions

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

For research use only. We do not sell to patients.

Saquinavir Chemical Structure

Saquinavir Chemical Structure

CAS No. : 127779-20-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 252 In-stock
Estimated Time of Arrival: December 31
100 mg USD 396 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Saquinavir:

Top Publications Citing Use of Products
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Description

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. IC50 Value: Target: HIV Protease Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.

Clinical Trial
Molecular Weight

670.84

Formula

C₃₈H₅₀N₆O₅

CAS No.

127779-20-8

SMILES

O=C(N[[email protected]@H](CC(N)=O)C(N[[email protected]@H](CC1=CC=CC=C1)[[email protected]](O)CN2[[email protected]](C(NC(C)(C)C)=O)C[[email protected]@](CCCC3)([H])[[email protected]@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (149.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4907 mL 7.4533 mL 14.9067 mL
5 mM 0.2981 mL 1.4907 mL 2.9813 mL
10 mM 0.1491 mL 0.7453 mL 1.4907 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.91%

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Saquinavir
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