1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease

Saquinavir (Synonyms: Ro 31-8959)

Cat. No.: HY-17007 Purity: 99.71%
Handling Instructions

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

For research use only. We do not sell to patients.
Saquinavir Chemical Structure

Saquinavir Chemical Structure

CAS No. : 127779-20-8

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $61 In-stock
10 mg $55 In-stock
50 mg $210 In-stock
100 mg $330 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. IC50 Value: Target: HIV Protease Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.

Clinical Trial
Sponsor Condition Start Date Phase
National Institutes of Health 2002-11-30 Phase 4
Royal Free and University College Medical School HIV-1 infection 2006-09-30 Phase 4
Hoffmann-La Roche Inc HIV infection 1999-11-02 Phase 4
The HIV Netherlands Australia Thailand Research Collaboration HIV-1 infection 2003-10-31 Phase 4
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.4907 mL 7.4533 mL 14.9067 mL
5 mM 0.2981 mL 1.4907 mL 2.9813 mL
10 mM 0.1491 mL 0.7453 mL 1.4907 mL






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

Purity: 99.71%

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