1. Anti-infection
    Metabolic Enzyme/Protease
    Autophagy
  2. HIV
    HIV Protease
    Autophagy
  3. Saquinavir Mesylate

Saquinavir Mesylate (Synonyms: Ro 31-8959/003)

Cat. No.: HY-17003 Purity: 99.79%
Handling Instructions

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

For research use only. We do not sell to patients.

Saquinavir Mesylate Chemical Structure

Saquinavir Mesylate Chemical Structure

CAS No. : 149845-06-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 190 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 3 publication(s) in Google Scholar

Other Forms of Saquinavir Mesylate:

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Description

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy. IC50 Value: Target: HIV Protease Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.

Clinical Trial
Molecular Weight

766.95

Formula

C₃₉H₅₄N₆O₈S

CAS No.

149845-06-7

SMILES

NC(C[[email protected]](C(N[[email protected]@H](CC1=CC=CC=C1)C(CN2C[[email protected]@]3([H])CCCC[[email protected]]3(C[[email protected]]2C(NC(C)(C)C)=O)[H])O)=O)NC(C4=NC5=CC=CC=C5C=C4)=O)=O.CS(O)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (26.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3039 mL 6.5193 mL 13.0387 mL
5 mM 0.2608 mL 1.3039 mL 2.6077 mL
10 mM 0.1304 mL 0.6519 mL 1.3039 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (2.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (2.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (2.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Saquinavir Mesylate
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HY-17003
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