149845-06-7
Chemical Structure
Saquinavir mesylate
Synonym(s): Ro 31-8959/003
- CAS No.: 149845-06-7
- Formula:C39H54N6O8S
- Molecular Weight:766.95
IUPAC Name: (S)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-phenylbutan-2-yl)-2-(quinoline-2-carboxamido)succinamide methanesulfonate
InChIKey: IRHXGOXEBNJUSN-YOXDLBRISA-N
SMILES: CS(=O)(O)=O.O=C(C1=NC2=C(C=CC=C2)C=C1)N[C@@H](CC(N)=O)C(N[C@@H](CC3=CC=CC=C3)[C@H](O)CN4[C@@H](C[C@@]5([H])[C@@](CCCC5)([H])C4)C(NC(C)(C)C)=O)=O
Biological Activity: Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Saquinavir mesylate | 99.40% | Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells. | ||||||||||||||||||||
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Saquinavir mesylate (Standard) | ≥98% | Saquinavir mesylate (Standard) (Ro 31-8959/003 (Standard)) is the analytical standard of Saquinavir mesylate (HY-17003). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells. | ||||||||||||||||||||
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References
- [1]. Waibel S, et al. Saquinavir Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2015;37(5):1973-82. [Content Brief]
- [2]. Pettoello-Mantovani M, et al. Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues. Antimicrob Agents Chemother. 1997 Sep;41(9):1880-7. [Content Brief]
- [3]. Yu Z, et al. Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways. Mediators Inflamm. 2017;2017:7083528. [Content Brief]
