1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease

Atazanavir sulfate (Synonyms: BMS-232632 sulfate)

Cat. No.: HY-17367A Purity: 99.64%
Data Sheet SDS Handling Instructions

Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.

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Atazanavir sulfate Chemical Structure

Atazanavir sulfate Chemical Structure

CAS No. : 229975-97-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $66 In-stock
10 mg $60 In-stock
50 mg $120 In-stock
100 mg $200 In-stock
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Other Forms of Atazanavir sulfate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Target: HIV-1 protease inhibitor Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. It has a pharmacokinetic profile that supports once-daily dosing and has demonstrated a unique resistance profile and superior virologic potency compared with other antiretrovirals in vitro. In subjects with HIV, atazanavir (400 mg once daily) produced rapid and sustained improvements in viral load and CD4 counts in both antiretroviral-naive as well as previously treated patients when used in combination with dual nucleoside reverse transcriptase inhibitor (NRTI) treatment [1]. After intravenous (iv), oral (po) and intraportal (ip) administration of ATV at a dosage of 7 mg/kg, AUCs in HL rats were 12.41, 5.24 and 8.89 microg/mLh, respectively, and were significantly higher than those in control rats (4.09, 1.70 and 3.38 microg/mLh). Despite the decrease of distribution volume (Vd(ss)), the terminal half-life (t(1/2)) in HL tended to be shorter than in control, and hepatic distribution of ATV in HL rats was 4.8-fold increases. These results suggested that the uptake of ATV into liver might counteract the decrease of Vd(ss). On the other hand, there was no significant difference in bioavailability, and the lymphatic transport to AUC showed no statistical change. In conclusion, although the protein binding rate and AUC were significantly increased, the pharmacokinetics of ATV might be tolerated in HL [2]. Clinical indications: HIV-1 infection Toxicity: torsades de pointes

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.2454 mL 6.2272 mL 12.4544 mL
5 mM 0.2491 mL 1.2454 mL 2.4909 mL
10 mM 0.1245 mL 0.6227 mL 1.2454 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

802.93

Formula

C₃₈H₅₄N₆O₁₁S

CAS No.

229975-97-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO; H2O: < 0.1 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Atazanavir sulfate
Cat. No.:
HY-17367A
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