1. NF-κB
    Autophagy
    Apoptosis
  2. Keap1-Nrf2
    Autophagy
    Apoptosis
    Ferroptosis
  3. Bardoxolone methyl

Bardoxolone methyl (Synonyms: RTA 402; NSC 713200; CDDO Methyl ester)

Cat. No.: HY-13324 Purity: 99.72%
Handling Instructions

Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.

For research use only. We do not sell to patients.

Bardoxolone methyl Chemical Structure

Bardoxolone methyl Chemical Structure

CAS No. : 218600-53-4

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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50 mg USD 100 In-stock
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100 mg USD 150 In-stock
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200 mg USD 250 In-stock
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500 mg USD 540 In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Bardoxolone methyl:

Top Publications Citing Use of Products

    Bardoxolone methyl purchased from MCE. Usage Cited in: Toxicol Lett. 2016 Sep 30;259:52-59.

    MATE1/SCL47A1 efflux transporter expression in hPTCs. Protein (n=3) expression is assessed after administration of NSC 119875 and pre- or delayedexposure to CDDO-Me after 12 h. GAPDH is used as a housekeeping gene. β-actin is used as a loading control.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.

    IC50 & Target

    Nrf2[1]

    In Vivo

    Bardoxolone methyl (30 mg/kg, p.o.) decreases renal expression of megalin but not cubilin, increases creatinine clearance and urinary albumin-to-creatinine ratios, and induces Nrf2 cytoprotective targets in cynomolgus monkeys[1]. Bardoxolone methyl induces overall favorable effects on the heart via its improvement in eGFR in both animal models and clinical trials[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    505.69

    Formula

    C₃₂H₄₃NO₄

    CAS No.

    218600-53-4

    SMILES

    O=C1C(C#N)=C[[email protected]@]2(C)[[email protected]](CC[[email protected]]([[email protected]@]3(C)[[email protected]@]4([H])[[email protected]@]5([H])[[email protected]@](CCC(C)(C)C5)(C(OC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (49.44 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9775 mL 9.8875 mL 19.7750 mL
    5 mM 0.3955 mL 1.9775 mL 3.9550 mL
    10 mM 0.1977 mL 0.9887 mL 1.9775 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

    • 3.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: 2.5 mg/mL (4.94 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [1]

    Two separate in-life studies are conducted in cynomolgus monkeys. In one study, cynomolgus monkeys (n=9/gender/dose group) are administered amorphous bardoxolone methyl by oral gavage, using sesame oil as the vehicle, at 5, 30, and 300 mg/kg once daily for 12 months in a GLP environment. Observations for morbidity, mortality, injury, and the availability of food and water are conducted twice daily for all animals. Clinical observations and body weights are conducted and recorded weekly. Weight data are analyzed by calculating the area under the weight versus time curve using the linear trapezoidal method. Blood samples for clinical chemistry evaluations are collected from all animals pretest and from all animals prior to interim (6-month) and terminal (12-month) necropsies. An additional group of monkeys for each dose group are allowed to recover for 4 weeks.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.72%

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    Keywords:

    Bardoxolone methylRTA 402 NSC 713200 CDDO Methyl esterRTA402RTA-402NSC713200NSC 713200NSC-713200Keap1-Nrf2AutophagyApoptosisFerroptosisInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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