Bardoxolone (Synonyms: CDDO; RTA 401)

Name: Bardoxolone
Brand: MedChemExpress
SKU: HY-14909
Rating: 5.0 (23 reviews)

Cat. No.: HY-14909 Purity: 99.50%: Data Sheet
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Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma.

For research use only. We do not sell to patients.

CAS No. : 218600-44-3

Size	Stock	Quantity

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Bardoxolone:

Bardoxolone methyl In-stock
Bardoxolone (Standard) Get quote

23 Publications Citing Use of MCE Bardoxolone

Cell Imaging/Staining

RT-PCR

Cell Proliferation/Viability Assay

Flow Cytometry

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]; NRF2/HMOX1 agonists inhibit SARS-CoV-2 replication. Fluorescence microscopy images of SARS-CoV-2 replication in NRF2/HMOX1 agonist-treated Vero-E6 cells. Vero-E6 cells were incubated with SARS-CoV-2 at an MOI of 0.01 for 1 h, and then treated with different NRF2/HMOX1 agonists, namely, Cobalt protoporphyrin (CoPP), Sulforaphane, or Bardoxolone for 24 h.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]; NRF2/HMOX1 agonists inhibit SARS-CoV-2 replication. Vero-E6 cells were incubated with SARS-CoV-2 at an MOI of 0.01 for 1 h, and then treated with different NRF2/HMOX1 agonists Bardoxolone (0.3 μM) for 24 h. The viral RNA copy number in the cell culture medium was determined by real-time PCR assay. The results are expressed as the mean ± SD (error bar) of 3 independent experiments; asterisks represent statistical significance based on two-tailed unpaired Student’s t test (*P < 0.05, **P < 0.01)

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Nature. 2020 Mar;579(7799):433-437. [Abstract]; Clonal HAP1 knockout and stably reconstituted cells were treated as indicated (CCCP, 20 μM, 9 h; Tunicamycin, HY-A0098, 10 μM, 9 h; Oligomycin (OM), 9 h; CDDO, Bardoxolone, HY-14909, 2.5 μM, 11 h; GTPP, HY-102007A, 10 μM, 11 h) and analysed by immunoblotting.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Nature. 2020 Mar;579(7799):433-437. [Abstract]; HAP1 CHOPNeon cells of the indicated genotypes were treated for 9 h (CCCP, 20 μM; Tunicamycin, HY-A0098, 10 μM; CDDO, Bardoxolone, HY-14909, 2.5 μM) or 12 h (GTPP, HY-102007A, 10 μM) and analysed by flow cytometry. Per genotype and treatment, the CHOPNeonsignal was normalized to its DMSO control and statistical significance is indicated compared to identically treated wild-type cells (mean ± s.d. of n = 3 independent experiments; one-way ANOVA with Dunnett’s multiple comparisons correction).

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; Triterpenoid CDDO inhibits both necroptosis and ferroptosis. HT-22 cells were pretreated with or without 10 μM CDDO (Bardoxolone) or 10 μM Nec-1s for 30 min and then treated with 20 ng/mL TNF-α (T), 20 nM SM-164 (S), and 20 μM zVAD.fmk (Z) for 3, 6, or 9 h. Cell viability was measured by CellTiterGlo assay.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; HT-22 cells were pretreated with 10 μM CDDO (Bardoxolone) and then treated with erastin (10 μM) for 8 h or T/S/Z for 4 h. Cell death was measured by PI uptake assay. Results shown are averages of triplicates ± SEM. **P < 0.01; ***P < 0.001; ****P < 0.0001.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; HT-22 cells were pretreated with or without 10 μM CDDO (Bardoxolone) or 10 μM Nec-1s for 30 min and then treated with 20 ng/mL human TNF-α (T), 20 nM SM-164 (S), and 50 μM zVAD.fmk (Z) for the indicated periods of time. The cell lysates were analyzed by Western blotting using the indicated antibodies.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; CDDO (Bardoxolone) inhibits ferroptosis by blocking GPX4 degradation. HT-22 cells were treated with the indicated stimuli for 6 h, followed by ROS measurement using the fluorescent probe carboxy-H2DCFDA.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; HT-22 cells were treated with the indicated stimuli (10 μM CDDO (Bardoxolone), 10 μM Erastin) for the indicated periods of time. The cell lysates were analyzed by Western blotting using the indicated antibodies.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; HT-29-HA-HSP90-α/β cells were treated with the indicated stimuli (10 μM CDDO (Bardoxolone), 1 μM 17AAG, 10 μM Nec-1s) for 12 h. The cell lysates were analyzed by immunoprecipitation using anti-HA and analyzed by Western blot using the indicated antibodies. Results shown are averages of triplicates ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

: Bardoxolone purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. [Abstract]; HT22 cells were pretreated with the indicated inhibitors (CDDO (Bardoxolone, HY-14909); T0070907 (HY-13202); Troglitazone (HY-50935 ); TPCA-1 (HY-10074); JAKi; STAT3i; AV-412 (HY-10346); and MK2206 (HY-10358)) and then treated with T/Z, T/S/Z, T/C/Z for 9 h or Glutamate, Erastin (T: 20 ng/ml; Z: 50 μM; S: 20 nM; C: 1 μg/ml; Glutamate: 50 mM; Erastin 10 μM) for 12 h. Cell viability was measured by CellTiterGlo assay.

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Nrf-2^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	1.3 μM Compound: 7; CDDO	Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalpha/SM-164/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalpha/SM-164/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay	[PMID: 33248849]
L929	EC₅₀	> 10 μM Compound: 7; CDDO	Anti-necroptotic activity in mouse L929 cells assessed as inhibition of TNFalpha/Z-VAD-fmk (TZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay Anti-necroptotic activity in mouse L929 cells assessed as inhibition of TNFalpha/Z-VAD-fmk (TZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay	[PMID: 33248849]
MCF7	EC₅₀	0.16 μM Compound: CDDO	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 3 days by radioactive thymidine incorporation assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 3 days by radioactive thymidine incorporation assay	[PMID: 26177446]
MCF7	IC₅₀	0.16 μM Compound: CDDO (1)	Inhibitory concentration against proliferation of MCF-7 (ER Positive) breast cancer cells Inhibitory concentration against proliferation of MCF-7 (ER Positive) breast cancer cells	[PMID: 15369396]
Macrophage	IC₅₀	0.0004 μM Compound: 4, CDDO	Antiinflammatory activity in mouse macrophages assessed as inhibition of IFN-gamma-induced nitric oxide production after 48 hrs by Griess method Antiinflammatory activity in mouse macrophages assessed as inhibition of IFN-gamma-induced nitric oxide production after 48 hrs by Griess method	[PMID: 23837912]
Macrophage	IC₅₀	0.5 nM Compound: CDDO	Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction	[PMID: 21361338]
Macrophage	IC₅₀	4.3 nM Compound: CDDO	Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction	[PMID: 21361338]
RAW	IC₅₀	0.02 μM Compound: CDDO	Inhibition of nitric oxide production in IFN-gamma stimulated RAW 264.7 cells Inhibition of nitric oxide production in IFN-gamma stimulated RAW 264.7 cells	[PMID: 16996735]
RAW	IC₅₀	20 nM Compound: CDDO	Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs	[PMID: 17367124]
RAW264.7	IC₅₀	11 nM Compound: CDDO, Bardoxolone	Inhibition of NO production in INFgamma-stimulated mouse RAW264.7 cells measured after 24 hrs by Griess reaction method Inhibition of NO production in INFgamma-stimulated mouse RAW264.7 cells measured after 24 hrs by Griess reaction method	[PMID: 21441026]
RAW264.7	IC₅₀	16.5 nM Compound: CDDO	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFNgamma-stimulated NO production pretreated for 2 hrs before IFNgamma challenge measured after 24 hrs by Griess reaction Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFNgamma-stimulated NO production pretreated for 2 hrs before IFNgamma challenge measured after 24 hrs by Griess reaction	[PMID: 22533790]
RAW264.7	IC₅₀	17 nM Compound: CDDO	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction	[PMID: 21361338]
RAW264.7	IC₅₀	23 nM Compound: CDDO	Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay	[PMID: 25965897]
RAW264.7	IC₅₀	28.3 nM Compound: CDDO	Antiinflammatory activity against IFN-gamma-stimulated mouse RAW264.7 cells assessed as nitrite accumulation after 24 hrs by Griess reagent method Antiinflammatory activity against IFN-gamma-stimulated mouse RAW264.7 cells assessed as nitrite accumulation after 24 hrs by Griess reagent method	[PMID: 20188548]

In Vitro

Bardoxolone (30 min) reversibly covalently inhibits SARS-CoV-2 3CLpro with an IC₅₀ of 27.99 ± 2.34 μM and a dissociation constant of 25.90 μM^[1].
Bardoxolone (48 h) inhibits SARS-CoV-2 replication in Vero and Calu-3 cells with EC₅₀ values of 0.43 and 0.42 μM and selective index of 56.6 and 28.2^[1].
Bardoxolone (10-100 nM) induces adipocyte differentiation in 3T3-L1 preadipocytes^[2].
Bardoxolone induces differentiation in acute promyelocytic leukemia cell lines (HL-60, NB4, MR2) and primary AML blasts via PPAR-γ-dependent mechanisms, including enhancement of ATRA-induced effects^[2].
Bardoxolone induces differentiation in osteosarcoma cells via a PPAR-γ-independent mechanism mediated by caspase-8 activity^[2].
Bardoxolone (1-10 μM) exerts antiproliferative and proapoptotic effects in lymphoma and colon cancer cells via inhibition of Lonp1 activity^[2].
Bardoxolone (1-10 μM) induces apoptosis in glioblastoma (U87MG, U251MG) and neuroblastoma (SK-N-MC) cell lines^[2].
Bardoxolone (1-10 μM) induces intrinsic pathway apoptosis in U-937 leukemia cells with increased ROS and decreased intracellular GSH^[2].
Bardoxolone (0.08-10 μM; pre-incubation + 12-16 h) inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 1.30 ± 0.38 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	CL_unbound	V_ss	T_1/2	F	AUC_0-24
Mice^[1]	0.1 mg/kg	i.v.	0.86 L/h/kg	3.1 L/h/kg	2.4 L/kg	1.9 h	/	/
Mice^[1]	5 mg/kg	p.o.	/	/	/	3.0 h	68 %	/
Rat^[1]	0.1 mg/kg	i.v.	0.72 L/h/kg	/	1.4 L/kg	1.3 h	/	/
Rat^[1]	5 mg/kg	p.o.	/	/	/	4.6 h	87 %	/
Dog^[1]	0.5 mg/kg	i.v.	0.22 L/h/kg	0.59 L/h/kg	1.27 L/kg	4.0 h	/	/
Dog^[1]	5 mg/kg	p.o.	/	/	/	3.7 h	46 %	/
Mice^[1]	0.03 mg/kg	p.o.	/	/	/	/	/	6.94 ng·h/mL

Clinical Trial

Molecular Weight

491.66

Formula

C₃₁H₄₁NO₄

CAS No.

218600-44-3

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (203.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0339 mL	10.1696 mL	20.3393 mL
5 mM	0.4068 mL	2.0339 mL	4.0679 mL
10 mM	0.2034 mL	1.0170 mL	2.0339 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

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Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.50%

Select Batch:

Data Sheet (283 KB) SDS (396 KB)

COA (252 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Sun Q, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. [Content Brief]

[2]. Borella R, et al. Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids. Molecules. 2019;24(22):4097. Published 2019 Nov 13. [Content Brief]

[3]. Wang Y, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. Eur J Med Chem. 2021;212:113030. [Content Brief]

Animal Administration
^[3]^[4]

Monkeys^[3]
Two separate studies are conducted in cynomolgus Monkeys. In one, cynomolgus Monkeys (n=9 per sex/dose group) are orally administered Bardoxolone methyl at 5, 30, and 300 mg/kg once daily for 12 months, with an interim analysis at 6 months and a postdose recovery analysis 4 weeks after the final dose, in a GLP environment. In a second study, female cynomolgus Monkeys (n=6 for vehicle and n=12 for treatment) are administered Bardoxolone methyl (30 mg/kg per day), as above, once daily for 28 days.
Mice^[4]
Male C57BL/6J mice are used. After 1 week of acclimatisation to the institutional animal facility (temperature 22°C, 12 h light/dark cycle), the animals are divided into three groups (n=7): (1) mice fed a normal diet (LFD group); (2) mice fed a high-fat diet (HFD group) (40% fat); and (3) mice fed the same HFD and supplemented with BARD in drinking water (10 mg/kg body weight) (HFD/BARD group). The dose and oral administration of BARD are chosen. After 21 weeks, all mice are euthanized using CO2 asphyxiation. Part of the mesenteric fat mass in each animal is collected and stored at −80°C for Western blot analysis. Another portion of the mesenteric fat depot is fixed in 4% paraformaldehyde and embedded in paraffin for the determination of morphology and immunohistochemistry.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Sun Q, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. [Content Brief]

[2]. Borella R, et al. Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids. Molecules. 2019;24(22):4097. Published 2019 Nov 13. [Content Brief]

[3]. Wang Y, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. Eur J Med Chem. 2021;212:113030. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0339 mL	10.1696 mL	20.3393 mL	50.8481 mL
	5 mM	0.4068 mL	2.0339 mL	4.0679 mL	10.1696 mL
	10 mM	0.2034 mL	1.0170 mL	2.0339 mL	5.0848 mL
	15 mM	0.1356 mL	0.6780 mL	1.3560 mL	3.3899 mL
	20 mM	0.1017 mL	0.5085 mL	1.0170 mL	2.5424 mL
	25 mM	0.0814 mL	0.4068 mL	0.8136 mL	2.0339 mL
	30 mM	0.0678 mL	0.3390 mL	0.6780 mL	1.6949 mL
	40 mM	0.0508 mL	0.2542 mL	0.5085 mL	1.2712 mL
	50 mM	0.0407 mL	0.2034 mL	0.4068 mL	1.0170 mL
	60 mM	0.0339 mL	0.1695 mL	0.3390 mL	0.8475 mL
	80 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6356 mL
	100 mM	0.0203 mL	0.1017 mL	0.2034 mL	0.5085 mL

Bardoxolone Related Classifications

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Bardoxolone (Synonyms: CDDO; RTA 401)

Customer Review

Other Forms of Bardoxolone:

23 Publications Citing Use of MCE Bardoxolone

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Bardoxolone (Synonyms: CDDO; RTA 401)

Customer Review

Other Forms of Bardoxolone:

Bardoxolone Related Antibodies

23 Publications Citing Use of MCE Bardoxolone

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View All NF-κB Isoform Specific Products:

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Biological Activity

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Purity & Documentation

References

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Bardoxolone Related Antibodies

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Complete Stock Solution Preparation Table

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