2. Anti-infection
    Metabolic Enzyme/Protease
  3. HIV Protease
    HIV
  4. Nelfinavir

Nelfinavir  (Synonyms: AG1341)

Cat. No.: HY-15287 Purity: 98.83%
COA Handling Instructions

Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.

For research use only. We do not sell to patients.

Nelfinavir Chemical Structure

Nelfinavir Chemical Structure

CAS No. : 159989-64-7

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Solution
10 mM * 1 mL in DMSO USD 125 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 125 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Nelfinavir:

Top Publications Citing Use of Products

    Nelfinavir purchased from MCE. Usage Cited in: Cells. 2022, 11(22), 3580

    Nelfinavir Mesylate (5 µM; 24 h) suppresses expression of MITF in A2058 and A375 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

    IC50 & Target[3]

    HIV-1

     

    In Vitro

    Nelfinavir (AG1341) (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells[4].
    Nelfinavir inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells[4].
    Nelfinavir (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines[4].
    Nelfinavir (5 μM; 0-24 hours) decreases the phosphorylation of AKT[4].
    Nelfinavir activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system[4].
    Nelfinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 35.93 μM[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[4]

    Cell Line: RPMI, LP1, U266, OPM2 and MM1S cells
    Concentration: 1, 2, 5, 10 μM
    Incubation Time: 48 hours
    Result: Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC50 of 1-5 μM.

    Apoptosis Analysis[4]

    Cell Line: LP1 and U266 cells
    Concentration: 1-10 μM
    Incubation Time: 17 hours
    Result: Induced a dose-dependent increase in the percentage of annexin V+/propidium iodide+ cells.

    Western Blot Analysis[4]

    Cell Line: U266 cells
    Concentration: 5 μM
    Incubation Time: 0-24 hours
    Result: The level of AKT phosphorylation in U266 cells decreased.
    In Vivo

    Nelfinavir (AG1341) (75 mg/kg; i.p.; 5 days a week for 21 days) decreases multiple myeloma cell growth in NOD/SCID mice[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NOD/SCID mice (bearing U266-luc cells)[4]
    Dosage: 75 mg/kg
    Administration: I.p.; 5 days a week for 21 days
    Result: Decreased MM cell growth in NOD/SCID mice.
    Clinical Trial
    Molecular Weight

    567.78

    Appearance

    Solid

    Formula

    C32H45N3O4S
    CAS No.
    SMILES

    [H][[email protected]]12C[[email protected]@H](C(NC(C)(C)C)=O)N(C[[email protected]]([[email protected]@H](NC(C3=C(C)C(O)=CC=C3)=O)CSC4=CC=CC=C4)O)C[[email protected]@]1([H])CCCC2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (176.12 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7612 mL 8.8062 mL 17.6125 mL
    5 mM 0.3522 mL 1.7612 mL 3.5225 mL
    10 mM 0.1761 mL 0.8806 mL 1.7612 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Nelfinavir159989-64-7AG1341AG 1341AG-1341HIV ProteaseHIVHuman immunodeficiency virusproteaseproliferationmultiplemyelomacellsphosphorylationNOproductioninfectionInhibitorinhibitorinhibit

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