Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

  • J Med Chem. 2016 Jun 9;59(11):5172-208. doi: 10.1021/acs.jmedchem.5b01697.
Arun K Ghosh  1 ,  Heather L Osswald  1 ,  Gary Prato  1
Affiliations
  • 1. Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.
PMID: 26799988 DOI: 10.1021/acs.jmedchem.5b01697
Abstract

HIV-1 Protease Inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic Infection. Over the years, intensive research has led to a variety of approved Protease Inhibitors for the treatment of HIV/AIDS. In this review, we outline current drug design and medicinal chemistry efforts toward the development of next-generation Protease Inhibitors beyond the currently approved drugs.