1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
  3. Darunavir

Darunavir (Synonyms: TMC114)

Cat. No.: HY-17040 Purity: 99.39%
Handling Instructions

Darunavir(TMC114) is an HIV protease inhibitor.

For research use only. We do not sell to patients.

Darunavir Chemical Structure

Darunavir Chemical Structure

CAS No. : 206361-99-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 210 In-stock
Estimated Time of Arrival: December 31
5 mg USD 174 In-stock
Estimated Time of Arrival: December 31
10 mg USD 318 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1176 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Darunavir(TMC114) is an HIV protease inhibitor. IC50 Value: Target: HIV Protease Darunavir HIV-1 antiviral structurally is similar to amprenavir and it is second generation HIV-1-protease inhibitor. Darunavir is a drug used to treat HIV infection. It is in the protease inhibitor class. Prezista is an OARAC recommended treatment option for treatment-naive and treatment-experienced adults and adolescents.

Clinical Trial
Molecular Weight

547.66

Formula

C₂₇H₃₇N₃O₇S

CAS No.

206361-99-1

SMILES

O=C(O[[email protected]@H]1[[email protected]@]2([H])[[email protected]@](OCC2)([H])OC1)N[[email protected]@H](CC3=CC=CC=C3)[[email protected]](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (182.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8260 mL 9.1298 mL 18.2595 mL
5 mM 0.3652 mL 1.8260 mL 3.6519 mL
10 mM 0.1826 mL 0.9130 mL 1.8260 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Darunavir
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HY-17040
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