1. Anti-infection
  2. Bacterial
  3. Bedaquiline

Bedaquiline (Synonyms: TMC207; R207910)

Cat. No.: HY-14881 Purity: 99.97%
Handling Instructions

Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.

For research use only. We do not sell to patients.

Bedaquiline Chemical Structure

Bedaquiline Chemical Structure

CAS No. : 843663-66-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Bedaquiline:

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Description

Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.

IC50 & Target

mycobacterial ATP synthase[1]

In Vitro

Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3].

Clinical Trial
Molecular Weight

555.50

Formula

C₃₂H₃₁BrN₂O₂

CAS No.

843663-66-1

SMILES

BrC1=CC=C(N=C(OC)C([[email protected]]([[email protected]@](C2=CC=CC3=C2C=CC=C3)(O)CCN(C)C)C4=CC=CC=C4)=C5)C5=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (36.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8002 mL 9.0009 mL 18.0018 mL
5 mM 0.3600 mL 1.8002 mL 3.6004 mL
10 mM 0.1800 mL 0.9001 mL 1.8002 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2 mg/mL (3.60 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2 mg/mL (3.60 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (3.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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Bedaquiline
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