2. Anti-infection
    Metabolic Enzyme/Protease
  3. HCV
    HCV Protease
    SARS-CoV
  4. Narlaprevir

Narlaprevir  (Synonyms: SCH 900518)

Cat. No.: HY-10300 Purity: 97.22%
COA Handling Instructions

Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM.

For research use only. We do not sell to patients.

Narlaprevir Chemical Structure

Narlaprevir Chemical Structure

CAS No. : 865466-24-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 737 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 737 In-stock
Solid
10 mg USD 670 In-stock
50 mg USD 1085 In-stock
100 mg USD 1896 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM[1]. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease[2]. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM[3].

IC50 & Target

Ki: 6 nM (NS3 protease) [1]
EC90: 40 nM (NS3 protease) [1]
Ki: 7 nM (ketoamide) [2]
EC90: 40 nM (replicon RNA) [2]
In Vitro

Narlaprevir (SCH 900518) potently inhibits ketoamide with a Ki value of 7 nM[2].
Narlaprevir (SCH 900518) potently inhibits replicon RNA with an EC90 value of 40 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Pharmacokinetic Analysis
Narlaprevir (SCH 900518) exhibits middle oral bioavailability (rat 46%, dog 29%, monkey 46 %) following oral administration (rat 10 mg/kg, dog 3 mg/kg, monkey 3 mg/kg )[1].
Narlaprevir (SCH 900518) exhibits moderate half-lives (rat 4.8 and dog 2 h) following intravenous administration (rat 4 and dog 1 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats, dogs, monkeys[1]
Dosage: Rat PO/IV 10/4 mg/kg; dog PO/IV 3/1 mg/kg; monkey PO 3 mg/kg
Administration: Intravenous (i.v.) or oral gavage
Result: T1/2s of 4.8 and 2 h for rats and dogs, respectively.
Clinical Trial
Molecular Weight

707.96

Appearance

Solid

Formula

C36H61N5O7S
CAS No.
SMILES

O=S(CC1(NC(N[[email protected]](C(N2[[email protected]@H]([[email protected]@]3([H])C(C)([[email protected]]3(C2)[H])C)C(N[[email protected]](C(C(NC4CC4)=O)=O)CCCC)=O)=O)C(C)(C)C)=O)CCCCC1)(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (70.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4125 mL 7.0625 mL 14.1251 mL
5 mM 0.2825 mL 1.4125 mL 2.8250 mL
10 mM 0.1413 mL 0.7063 mL 1.4125 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.15%

COA (260 KB) HNMR (228 KB) RP-HPLC (244 KB) MS (70 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Narlaprevir865466-24-6SCH 900518SCH900518SCH-900518HCVHCV ProteaseSARS-CoVHepatitis C virusSARS coronavirusselectivehepatitisInhibitorinhibitorinhibit

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