1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Ombitasvir (Synonyms: ABT-267)

Cat. No.: HY-13997 Purity: 99.89%
Handling Instructions

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

For research use only. We do not sell to patients.

Ombitasvir Chemical Structure

Ombitasvir Chemical Structure

CAS No. : 1258226-87-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 148 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 530 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 940 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

IC50 & Target

EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a)[1]

In Vitro

Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively[1]. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (36.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1184 mL 5.5922 mL 11.1843 mL
5 mM 0.2237 mL 1.1184 mL 2.2369 mL
10 mM 0.1118 mL 0.5592 mL 1.1184 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

894.11

Formula

C₅₀H₆₇N₇O₈

CAS No.

1258226-87-7

SMILES

CC(C)(C)C(C=C1)=CC=C1N2[[email protected]](C3=CC=C(NC([[email protected]]4N(C([[email protected]@H](NC(OC)=O)C(C)C)=O)CCC4)=O)C=C3)CC[[email protected]]2C5=CC=C(NC([[email protected]@H]6CCCN6C([[email protected]@H](NC(OC)=O)C(C)C)=O)=O)C=C5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Ombitasvir
Cat. No.:
HY-13997
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Ombitasvir

Cat. No.: HY-13997