Nucleoprotein/NP Protein, H1N1 (EPI1716625, sf9, His)

Influenza virus nucleoprotein (NP) is a structural protein that coats viral negative-strand RNA. NP proteins protect viral RNA from degradation by cellular enzymes during the viral life cycle, fit the helical structure of RNP, regulate transcription and replication of viral RNA templates in a histone-like manner, and induce immunosuppression during infection. Nucleoprotein/NP Protein, H1N1 (EPI1716625, sf9, His) is the recombinant Virus-derived Nucleoprotein/NP protein, expressed by Sf9 insect cells , with C-His labeled tag.

Influenza virus nucleoprotein (NP) is a structural protein that coats viral negative-strand RNA. NP is one of the main determinants of species specificity. The extent to which NP genes can be reprogrammed to cross the species barrier and adapt to a new host by mutation. NP proteins protect viral RNA from degradation by cellular enzymes during the viral life cycle, fit the helical structure of RNP, regulate transcription and replication of viral RNA templates in a histone-like manner, and induce immunosuppression (inhibition of effector cytokine synthesis and FcR drug signaling) during infection. NP is a very promising target for future vaccine development^[1][2].

Virus

Sf9 insect cells

C-His

EPI1716625 (M1-N498)

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≥ 85%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.