CD64 Protein, Rabbit (HEK293, His)
Based on 1 Customer Validation
The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD64 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Rabbit
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD64 protein, expressed by HEK293 , with C-His labeled tag.
CD64 Protein emerges as a high-affinity receptor specifically designed for the Fc region of immunoglobulins gamma, playing a pivotal role in both innate and adaptive immune responses. Its dynamic functionality extends to forming a functional signaling complex through interaction with FCERG1. Additionally, CD64 interacts with FLNA, preventing FCGR1A degradation, and engages with EPB41L2, LAT, and PPL in intricate cellular processes. Furthermore, this receptor establishes connections with HCK and LYN, showcasing its versatility and involvement in various signaling cascades critical for immune system modulation.
Measured by its binding ability in a functional ELISA. Immobilized Rabbit CD64 at 1μg/mL (100μL/well) can bind biotinylated Rabbit IgG. The ED50 for this effect is 1.224 μg/mL.
Technical Parameters
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Species Rabbit
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Source HEK293
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Tag C-6*His
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Accession
XP_008262732.1 (Q16-F291)
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Gene ID100358696 [NCBI]
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Molecular Construction
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N-term
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CD64 (Q16-F291)
Accession # XP_008262732.1 -
His
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C-term
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Protein Length
Partial
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Synonyms
High affinity immunoglobulin gamma Fc receptor I; Fcgr1; FcRI; CD64; Fc receptor; IgG; high affinity I
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AA Sequence
MWLWTALLLWVPVGGQEDPTKAVITLQPPWVDVFQEEAVTLQCEGPRQPGDSSAQWFLNGTAIRTLTPRYYITGAQANDSGEYRCQTELSAPSEPVQLQAHRDWLLLQVSGRVFTEGEPLTMRCHAWKNKIVYNVLFYQNGKAFKFSSQDSELTIPKTNVNHNGIYHCSAMGRYRYTSAGVSVTVQELFRVPVLRASSPLPLQEGSAVTLSCETKLLPDSPALRLYFSFYVGNKTVQARNVSSQYQIPRVGGEDLGLYWCEAATEDGGVRKCSVVLELGVLGSQAPNPVWF
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Molecular Weight
Approximately 40-47 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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