HCK
HCK (hematopoietic cell kinase) is a myristoylated Src-family tyrosine kinase expressed predominantly in granulocytes, monocytes and macrophages. Downstream of Fc-gamma, integrin and cytokine receptors, HCK participates in neutrophil chemotaxis, degranulation and the respiratory burst that generates microbicidal reactive oxygen species, and it regulates macrophage cytokine release and podosome formation. The HIV-1 Nef protein exploits HCK, binding its SH3 domain with high affinity to activate the kinase and perturb myeloid cell function during infection. Elevated HCK activity contributes to differentiation arrest in acute myeloid leukemia and chronic myelomonocytic leukemia, and dasatinib and other Src-family inhibitors can induce differentiation responses, making HCK a pharmacologically relevant kinase in myeloid disease.
-
HCK Recombinant Proteins (3)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
