HCK Protein, Human (Active, Q523E, Q524E, Q525I, sf9)

HCK Protein, a non-receptor tyrosine-protein kinase predominantly found in hematopoietic cells, serves as a pivotal mediator transmitting signals from various cell surface receptors and playing a crucial role in the regulation of innate immune responses. It intricately modulates functions in neutrophils, monocytes, macrophages, and mast cells, influencing processes such as phagocytosis, cell survival, proliferation, adhesion, and migration. Acting downstream of receptors including FCGR1A, FCGR2A, CSF3R, PLAUR, IFNG, IL2, IL6, IL8, and integrins ITGB1 and ITGB2, HCK orchestrates critical events during the phagocytic process, including mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase, leading to the respiratory burst and release of inflammatory molecules. Additionally, HCK promotes the reorganization of the actin cytoskeleton, actin polymerization, formation of podosomes, and cell protrusions. It inhibits TP73-mediated transcription activation and apoptosis while phosphorylating key signaling proteins such as CBL, ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1, and WAS, highlighting its extensive involvement in diverse cellular pathways.