VTI1A Protein, Human (HEK293, Fc)

VTI1A Protein, a V-SNARE, mediates vesicle transport by interacting with t-SNAREs on target membranes, facilitating lipid bilayer fusion. It plays a role in vesicular transport from late endosomes to the trans-Golgi network. Collaborating with VAMP7, it participates in a non-conventional RAB1-dependent route to the cell surface used by KCNIP1 and KCND2. VTI1A interacts with SNARE complexes containing STX5 or STX6, NAPA, and to a lesser extent, NAPG. It is part of a complex with STX6, STX12, VAMP4, and VTI1A. VTI1A Protein, Human (HEK293, Fc) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-mFc labeled tag. The total length of VTI1A Protein, Human (HEK293, Fc) is 187 a.a., with molecular weight of ~48.5 kDa.

VTI1A, a vesicle-associated soluble N-ethylmaleimide-sensitive factor attachment protein receptor (V-SNARE), plays a crucial role in mediating vesicle transport pathways through interactions with target membrane t-SNAREs, contributing to the specificity of vesicle trafficking and facilitating lipid bilayer fusion. This protein is implicated in vesicular transport from late endosomes to the trans-Golgi network and participates, along with VAMP7, in a non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. Additionally, VTI1A may be associated with increased cytokine secretion observed during cellular senescence. It interacts with distinct SNARE complexes containing either STX5 or STX6, and forms a complex with NAPA and, to a lesser extent, with NAPG. Furthermore, VTI1A is identified in a complex alongside STX6, STX12, VAMP4, and itself, highlighting its role in diverse intracellular trafficking processes.

Human

HEK293

N-mFc

Q96AJ9-2 (M1-R187)

143187  [NCBI]

Approximately 48.5 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.