Anti-Mouse IL-1a Antibody (ALF-161)
Based on 1 Customer Validation
Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for researches on immune response and cancer such as breast cancer.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Armenian Hamster IgG
Mouse
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IL-1α |
Anti-Mouse IL-1a Antibody (200 µg, i.p., once every 3 days, until the end of the experiment) can reversibly transform myeloid cell expansion and improve T cell function in wild-type female C57BL/6 mice bearing AT3 tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×109 vg AAV-OVA injected C57BL/6J mice (6-8 weeks)[1]
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Dosage:200 μg, combined with IL-1b mAb (HY-P99139) (200 μg)
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Administration:Intraperitoneal injection (i.p.), twice weekly, for 4 weeks
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Result:Reduced the response rate from 67 % to 33 % and lowered the frequency by about three times when used alone.
Further reduced the response rate to 19 %-20 % when combined with IL-1b mAb.
Slightly reduced anti OVA IgG2c but did not affect anti capsid antibodies.
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Animal Model:5×105 AT3 cells injected wild-type female C57BL/6 mice (8-10 weeks)[2]
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Dosage:200 μg, combined with IL-1R mAb (HY-P99140) (200 μg)
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Administration:Intraperitoneal injection (i.p.), once every 3 days until the end of the experiment
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Result:Significantly reduced the expansion of neutrophils and immature CD11b+ myeloid cells in the spleen.
Prevented a decrease in T cell subpopulations, such as initial and central memory CD8+ T cells.
Reduced circulating G-CSF levels.
Effectively restored APC function and T cell response when combined with IL-1R mAb.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo IL-1α neutralization; in vitro IL-1α neutralization
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-1a Antibody (ALF-161)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Kumar SRP, et al. TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. Mol Ther. 2024 Feb 7;32(2):325-339. [Content Brief]
[2]. Allen BM, et al. Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med. 2020 Jul;26(7):1125-1134. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-1a Antibody (ALF-161) Related Classifications
HY-P99138 Related Classifications
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