Il1a - interleukin 1 alpha Gene

Also Known as Il-1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16175

About Il1a

Chromosome 2: 129,141,530-129,151,892 reverse strand.GRCm39:CM000995.3

This gene has 1 transcript (splice variant), 92 orthologues and is associated with 8 phenotypes. Broad expression in liver E18 (RPKM 1.2), liver E14 (RPKM 1.1) and 2 other tissues.

Summary

Enables cytokine activity and interleukin-1 receptor binding activity. Involved in positive regulation of angiogenesis and positive regulation of vascular endothelial growth factor production. Acts upstream of or within several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Located in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il1a Products (1)

mRNA Protein Name
NM_010554.4 NP_034684.2 interleukin-1 alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
23395675 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within connective tissue replacement involved in inflammatory response wound healing IMP
IMP: Inferred from mutant phenotype
15784728 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: Inferred from genetic interaction
11536012 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
11536012 MGI
acts upstream of or within interleukin-33 production IDA
IDA: Inferred from direct assay
32484881 MGI
acts upstream of or within intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
19766171 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12598651 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19666510 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
12598651 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21148126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1a Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 110)

IL1

IL1: smart00125 (130 - 269)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

interleukin-1 alpha

  • IL-1 alpha

Recombinant Il1a Proteins

Cat. No. Product Name Accession Purity
HY-P7072 IL-1 alpha Protein, Mouse P01582 (S115-S270) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700186AF Animal-Free IL-1 alpha Protein, Mouse (His) P01582 (S115-S270) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171657 4'-Acetoxy resveratrol 99.90% Unkown
HY-P4542 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) Antagonist / Unkown
HY-RS06713 IL1A Human Pre-designed siRNA Set A / Unkown
HY-RS06714 Il1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06715 Il1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174628 Human IL1A mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99138 Anti-Mouse IL-1a Antibody (ALF-161) Inhibitor ≥95.0% Unkown
HY-P991008 Lunlekitug Inhibitor 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1a NCBI NCBI:3552