2. Gene
  3. Il1a - interleukin 1 alpha Gene

Il1a - interleukin 1 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il-1a

Gene ID: 16175 | Gene type: protein coding

About Il1a

Chromosome 2: 129,141,530-129,151,892 reverse strand.GRCm39:CM000995.3

This gene has 1 transcript (splice variant), 92 orthologues and is associated with 8 phenotypes. Broad expression in liver E18 (RPKM 1.2), liver E14 (RPKM 1.1) and 2 other tissues.

Summary

Enables cytokine activity and interleukin-1 receptor binding activity. Involved in positive regulation of angiogenesis and positive regulation of vascular endothelial growth factor production. Acts upstream of or within several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Located in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il1a Products(1)

mRNA Protein Name
NM_010554.4 NP_034684.2 interleukin-1 alpha

Il1a Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 110)

IL1

IL1: smart00125 (130 - 269)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

interleukin-1 alpha

IL-1 alpha

Recombinant Il1a Proteins

Cat. No. Product Name Accession Purity
HY-P7072 IL-1 alpha Protein, Mouse Q3U0Y6 (S115-S270) ≥95%
HY-P70436 IL-1F1, Mouse P01582 ≥95%
HY-P700186AF Animal-Free IL-1 alpha Protein, Mouse (His) P01582 (S115-S270) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P4542 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) Antagonist / Unkown
HY-RS06713 IL1A Human Pre-designed siRNA Set A / Unkown
HY-RS06714 Il1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS06715 Il1a Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99138 Anti-Mouse IL-1a Antibody (ALF-161) Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1a NCBI NCBI:3552
Macaca fascicularis Il1a NCBI NCBI:101926546
Susscrofa domestica Il1a NCBI
Rattus norvegicus Il1a NCBI NCBI:24493
Macaca mulatta Il1a NCBI NCBI:700193