2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-1a Antibody (ALF-161)

Anti-Mouse IL-1a Antibody (ALF-161) 

Cat. No.: HY-P99138 Purity: ≥95.0%
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Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for researches on immune response and cancer such as breast cancer.

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Anti-Mouse IL-1a Antibody (ALF-161)

Anti-Mouse IL-1a Antibody (ALF-161) 화학구조

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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제품 설명

Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for researches on immune response and cancer such as breast cancer[1][2].

Isotype

Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][2]

IL-1α

 

In Vivo

Anti-Mouse IL-1a Antibody (200 μg, i.p., twice weekly, for 4 weeks) can inhibit CD8+ T cell response in C57BL/6J mice injected with adeno-associated viral-ovalbumin (AAV-OVA)[1].
Anti-Mouse IL-1a Antibody (200 µg, i.p., once every 3 days, until the end of the experiment) can reversibly transform myeloid cell expansion and improve T cell function in wild-type female C57BL/6 mice bearing AT3 tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×109 vg AAV-OVA injected C57BL/6J mice (6-8 weeks)[1]
Dosage: 200 μg, combined with IL-1b mAb (HY-P99139) (200 μg)
Administration: Intraperitoneal injection (i.p.), twice weekly, for 4 weeks
Result: Reduced the response rate from 67 % to 33 % and lowered the frequency by about three times when used alone.
Further reduced the response rate to 19 %-20 % when combined with IL-1b mAb.
Slightly reduced anti OVA IgG2c but did not affect anti capsid antibodies.
Animal Model: 5×105 AT3 cells injected wild-type female C57BL/6 mice (8-10 weeks)[2]
Dosage: 200 μg, combined with IL-1R mAb (HY-P99140) (200 μg)
Administration: Intraperitoneal injection (i.p.), once every 3 days until the end of the experiment
Result: Significantly reduced the expansion of neutrophils and immature CD11b+ myeloid cells in the spleen.
Prevented a decrease in T cell subpopulations, such as initial and central memory CD8+ T cells.
Reduced circulating G-CSF levels.
Effectively restored APC function and T cell response when combined with IL-1R mAb.
Gene ID

16175  [NCBI]

Accession
Application

in vivo IL-1α neutralization; in vitro IL-1α neutralization
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
분자량

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-1a Antibody (ALF-161)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Anti-Mouse IL-1a Antibody (ALF-161) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1a Antibody (ALF-161)Interleukin RelatedILIL-1aCD8T cellImmunologyAT3breast cancerInhibitorinhibitorinhibit

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상품명:
Anti-Mouse IL-1a Antibody (ALF-161)
Cat. No.:
HY-P99138
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