2. Epigenetics
  3. Epigenetic Reader Domain
  4. BAZ1A-IN-1

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A.

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BAZ1A-IN-1 Chemical Structure

BAZ1A-IN-1 Chemical Structure

CAS No. : 941521-45-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
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10 mg USD 450 In-stock
50 mg USD 1350 In-stock
100 mg USD 2090 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

BAZ1A-IN-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

IC50 & Target

BAZ1A[1]
In Vitro

BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAZ1A-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
Concentration: 0.015-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.
Molecular Weight

340.36

Formula

C16H12N4O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=CC([N+]([O-])=O)=C1)NC2=NC(C3=CC=CC=C3)=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9381 mL 14.6903 mL 29.3807 mL 73.4516 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL 14.6903 mL
10 mM 0.2938 mL 1.4690 mL 2.9381 mL 7.3452 mL
15 mM 0.1959 mL 0.9794 mL 1.9587 mL 4.8968 mL
20 mM 0.1469 mL 0.7345 mL 1.4690 mL 3.6726 mL
25 mM 0.1175 mL 0.5876 mL 1.1752 mL 2.9381 mL
30 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4484 mL
40 mM 0.0735 mL 0.3673 mL 0.7345 mL 1.8363 mL
50 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4690 mL
60 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
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BAZ1A-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAZ1A-IN-1941521-45-5Epigenetic Reader DomainBAZ1Abromodomain-containingcancerTHP-10leukemiaZR-75–30breast cancerBT474H1975lung cancerInhibitorinhibitorinhibit

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