BAZ1A-IN-1
Based on 1 publication(s) in Google Scholar
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 941521-45-5
- Formula: C16H12N4O3S
- Molecular Weight:340.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BAZ1A-IN-1
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Biological Activity
BAZ1A[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human BEL7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BEL7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
| BT-474 | IC50 |
10.65 μM
Compound: 2
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Cytotoxicity against human BT474 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BT474 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
| NCI-H1975 | IC50 |
7.7 μM
Compound: 2
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Cytotoxicity against human H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
| THP-1 | IC50 |
5.08 μM
Compound: 2
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Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
| U-87MG ATCC | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
| ZR-75-30 | IC50 |
4.29 μM
Compound: 2
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Cytotoxicity against human ZR-75-30 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human ZR-75-30 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33333161] |
BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
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Concentration:0.015-100 μM
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Incubation Time:96 hours
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Result:Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.
Chemical Information
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CAS No. 941521-45-5
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Appearance Solid
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Molecular Weight 340.36
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Formula C16H12N4O3S
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=CC([N+]([O-])=O)=C1)NC2=NC(C3=CC=CC=C3)=CS2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9381 mL | 14.6903 mL | 29.3807 mL | 73.4516 mL |
| 5 mM | 0.5876 mL | 2.9381 mL | 5.8761 mL | 14.6903 mL | |
| 10 mM | 0.2938 mL | 1.4690 mL | 2.9381 mL | 7.3452 mL | |
| 15 mM | 0.1959 mL | 0.9794 mL | 1.9587 mL | 4.8968 mL | |
| 20 mM | 0.1469 mL | 0.7345 mL | 1.4690 mL | 3.6726 mL | |
| 25 mM | 0.1175 mL | 0.5876 mL | 1.1752 mL | 2.9381 mL | |
| 30 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4484 mL | |
| 40 mM | 0.0735 mL | 0.3673 mL | 0.7345 mL | 1.8363 mL | |
| 50 mM | 0.0588 mL | 0.2938 mL | 0.5876 mL | 1.4690 mL | |
| 60 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL |
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