Xanthone V1a 

Xanthone V1a, a derivative of Xanthone (HY-N0126), is an antioxidant that can be found in the roots of Cudrania tricuspidata and twig extracts of Maclura fruticosa. Xanthone V1a exerts cytotoxic effects against colon, hepatocellular, and gastric carcinoma cells. Xanthone V1a exhibits scavenging activitys against DPPH and ABTS. Xanthone V1a can be used for the research of colon carcinoma, hepatocellular carcinoma, and gastric carcinoma^[1][2].

Xanthone V1a (72 h) exhibits significant cytotoxicity against HCT-116, SMMC-7721, and SGC-7901 cell lines with IC₅₀ values of 0.3, 6.2, and 3.4 μg/mL, respectively, showing no cytotoxicity against BGC-823 cells^[1].
Xanthone V1a (30 min) shows significant anti-oxidant activity against the DPPH radical an IC50 of 10.43 μM^[2].
Xanthone V1a (200 μg/mL, 5 min) inhibits ABTS with an inhibition of 93.69%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.43

C₂₃H₂₄O₆

103450-96-0

C/C(C)=C\CC(C(O)=C12)=C(O)C(C/C=C(C)\C)=C2OC3=C(C=CC(O)=C3O)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zou YS, et al. Cytotoxic isoprenylated xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2004 Apr 15;12(8):1947-53.  [Content Brief]

  [2]. Isaraporn Polbuppha, et al. Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of
  Compounds isolated from the Twig Extracts of Maclura fruticosa. Natural Product Communications Vol. 12 (7) 2017.