UGT1A7 Protein, Human (Cell-Free, His)

The UGT1A7 protein is a UDP-glucuronosyltransferase (UGT) that plays a key catalytic role in phase II reactions, conjugating lipophilic substrates with glucuronic acid to enhance water solubility and promote excretion. This enzymatic activity is critical for the elimination of drugs, xenobiotics, and endogenous compounds. UGT1A7 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT1A7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT1A7 Protein, Human (Cell-Free, His) is 505 a.a., with molecular weight of 60.0 kDa.

UGT1A7 is a UDP-glucuronosyltransferase (UGT) that plays a pivotal role in phase II biotransformation reactions, facilitating the conjugation of lipophilic substrates with glucuronic acid to enhance water solubility and promote excretion into urine or bile. This enzymatic activity is crucial for the elimination and detoxification of drugs, xenobiotics, and endogenous compounds. UGT1A7 is involved in the glucuronidation of various substances, including endogenous estrogen hormone epiestradiol, phytoestrogens like genistein and daidzein, the angiotensin receptor antagonist caderastan, and the active metabolite of the anticancer drug irinotecan, SN-38. Additionally, it participates in the biotransformation of mycophenolate, an immunosuppressive agent. Notably, while UGT1A7 lacks glucuronidation activity itself, it serves as a negative regulator of isoform 1.

Human

E. coli Cell-free

N-10*His

Q9HAW7 (G26-H530)

54577

GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

60.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.