Immune initiator-1
Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma.
For research use only. We do not sell to patients.
- CAS No.: 3036258-19-9
- Formula: C41H32BF2IN4O7
- Molecular Weight:868.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
>250 μM
Compound: 1a
|
Dark toxicity against human A-375 cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
Dark toxicity against human A-375 cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
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[PMID: 35152702] |
| A-375 | IC50 |
0.081 μM
Compound: 1a
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Phototoxicity against human A-375 cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
Phototoxicity against human A-375 cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
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[PMID: 35152702] |
| B16-F10 | IC50 |
>250 μM
Compound: 1a
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Dark toxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
Dark toxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
|
[PMID: 35152702] |
| B16-F10 | IC50 |
0.065 μM
Compound: 1a
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Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
|
[PMID: 35152702] |
| HeLa | IC50 |
>250 μM
Compound: 1a
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Dark toxicity against human HeLa cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
Dark toxicity against human HeLa cells assessed as reduction in cell viability incubated for 16 hrs by CCK-8 assay
|
[PMID: 35152702] |
| HeLa | IC50 |
0.021 μM
Compound: 1a
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Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 16 hrs followed by irradiated with 54 J/cm^2 of light dose and further incubated for 24 hrs by CCK-8 assay
|
[PMID: 35152702] |
Chemical Information
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CAS No. 3036258-19-9
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Molecular Weight 868.43
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Formula C41H32BF2IN4O7
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SMILES
[F-][B+3]1([N-]2C3=C(CCC4=CC(OCC(N[C@H](C(O)=O)CC(O)=O)=O)=CC=C43)C(C5=CC=CC=C5)=C2N=C6[N]1=C(C7=CC=C(C=C7)OC)C(I)=C6C8=CC=CC=C8)[F-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Immune initiator-1 Related Classifications
HY-D1453 Related Classifications
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