1. Anti-infection
  2. HCV
  3. SMCypI C31

SMCypI C31 

Cat. No.: HY-125182
Handling Instructions

SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction.

For research use only. We do not sell to patients.

SMCypI C31 Chemical Structure

SMCypI C31 Chemical Structure

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Description

SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction[1][2].

IC50 & Target

IC50: 0.1 µM (Peptidyl-prolyl cis/trans isomerases (PPIase))[2]

In Vitro

SMCypI C31 (C31) inhibited the replication of genotype 1a, 1b, 2a, 3a, and 5a HCV-SGRs and chimeric genotype 2a/4a HCV-SGRs, with EC50 values of 3.80 µM, 2.95 µM, 2.30 µM, 7.76 µM, 1.20 µM and 1.40 µM, respectively[1].
SMCypI C31 also inhibits the replication of the infectious J6/JFH1 virus, with an EC50 of 2.80 μM. SMCypI C31 inhibits DBN-3acc RNA replication in a dose-dependent manner, with a maximal 244-fold HCV RNA reduction at 10 μM[1].
SMCypI C31 (C31) inhibits the replication of other members of the Flaviviridae family. SMCypI C31 inhibits viral replication of DENV (EC50 of 7.3 μM), YFV (EC50 of 27.2 μM), and ZIKV (EC50 of 48.0 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

474.62

Formula

C₂₇H₃₀N₄O₂S

SMILES

O=C(NC(C1=CC=CC=C1)C(N2C(C3=CC=CC=C3SC)CCC2)=O)NCC4=CC=C(N)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SMCypI C31SMCypI C 31SMCypI C-31HCVHepatitis C virusPPIasenon-peptidicCypA-NS5Acyclophilinpangenotypeanti-HCVInhibitorinhibitorinhibit

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SMCypI C31
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HY-125182
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