Cyclophilin C

Cyclophilin C (CypC/PPIC) is a peptidyl-prolyl cis-trans isomerase that supports protein folding in the endoplasmic reticulum and binds cyclosporin A^[1]^[2]. Mechanistically, CypC acts with cyclophilin B in ER redox homeostasis, because combined depletion altered transferrin secretion, albumin oxidative folding, protein-disulfide isomerase oxidation, and oxidized glutathione balance^[2]. In an HCMV immune-evasion model, CypC co-isolated with US2 and HLA-A2, and either depletion or overexpression impaired US2-mediated MHC class I degradation^[3]. Compared with related isoforms, extracellular CypA and CypC increased IL-6, MCP-1, CD147, and NF-κB-p65 activation in pancreatic microendothelial cells, whereas extracellular CypB did not affect these pro-inflammatory markers^[4]. For experimental applications, cyclosporin A binds CypC, reversed extracellular CypC-driven endothelial responses, and induced ER depletion of cyclophilins B and C in redox studies^[1]^[2]^[4]. Serum CypC was also associated with coronary artery disease risk, supporting its use as a biomarker candidate rather than a validated therapeutic target^[5].

References:

[1]. Schneider H, et al. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. Biochemistry. 1994 Jul 12;33(27):8218-24. [Content Brief]

[2]. Stocki P, et al. Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis. J Biol Chem. 2014 Aug 15;289(33):23086-23096. [Content Brief]

[3]. Chapman DC, et al. Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules. PLoS One. 2015 Dec 21;10(12):e0145458. [Content Brief]

[4]. Alvariño R, et al. Extracellular cyclophilins A and C induce dysfunction of pancreatic microendothelial cells. Front Physiol. 2022 Oct 5;13:980232. [Content Brief]

[5]. Alfonso A, et al. High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease. Sci Rep. 2019 Jul 22;9(1):10576. [Content Brief]

Cyclophilin C Inhibitor (1)

Cyclophilin C Related Products (1):

Cat. No.	Product Name	Effect	Purity

HY-151489

CypE-IN-1	Inhibitor
CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC₅₀ and K_i values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.

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