3023438-33-4
Chemical Structure
CypE-IN-1
- CAS No.: 3023438-33-4
- Formula:C46H49BN6O9
- Molecular Weight:840.73
IUPAC Name: (4'-(((13S,4S,12S,E)-13-benzyl-12-carbamoyl-2,5,10,16,19-pentaoxo-3,6,11,15-tetraaza-1(3,1)-piperidina-8(1,2)-benzenacyclononadecaphan-17-en-4-yl)methyl)-4-formyl-[1,1'-biphenyl]-3-yl)boronic acid
InChIKey: UNKUVNABSDHRGB-UJYFWDSGSA-N
SMILES: [H]C(C1=C(C=C(C=C1)C2=CC=C(C=C2)C[C@@H]3NC([C@@]4(CCCN(C(/C=C/C(NCC[C@H](NC(CC5=C(CNC3=O)C=CC=C5)=O)C(N)=O)=O)=O)C4)CC6=CC=CC=C6)=O)B(O)O)=O
Biological Activity: CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].
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CypE-IN-1 | CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes. | |||||||||||||||||||||
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Keywords
