CypE-IN-1
CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 3023438-33-4
- Formula: C46H49BN6O9
- Molecular Weight:840.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cyclophilin Isoforms
More
Biological Activity
|
Cyclophilin D 0.6 μM (IC50) |
Cyclophilin A 3 μM (IC50) |
Cyclophilin B 4 μM (IC50) |
Cyclophilin E 0.013 μM (IC50) |
Cyclophilin C 17 μM (IC50) |
Cyclophilin G 40 μM (IC50) |
Cyclophilin D 0.52 μM (Ki) |
Cyclophilin A 1.8 μM (Ki) |
Cyclophilin B 5.6 μM (Ki) |
Cyclophilin E 0.072 μM (Ki) |
CypE-IN-1 (C3A) has selectivity for CypD, CypA, CypB and CypE with Ki values of 0.52 μM, 1.8 μM, 5.6 μM and 0.072 μM, respectively[1].
CypE-IN-1 has inhibitory activity for CypD, CypA, CypB, CypE, CypC and CypG with IC50 values of 0.6 μM, 3 μM, 4 μM, 0.013 μM, 17 μM and 40 μM, respectively[1].
CypE-IN-1 has binding and inhibition potency for CypE K212A, K217A and K218A mutants with IC50 values of 0.03 μM, 2 μM and 0.019 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3023438-33-4
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Molecular Weight 840.73
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Formula C46H49BN6O9
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SMILES
[H]C(C1=C(C=C(C=C1)C2=CC=C(C=C2)C[C@@H]3NC([C@@]4(CCCN(C(/C=C/C(NCC[C@H](NC(CC5=C(CNC3=O)C=CC=C5)=O)C(N)=O)=O)=O)C4)CC6=CC=CC=C6)=O)B(O)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CypE-IN-1 Related Classifications
HY-151489 Related Classifications
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