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Cat. No.: HY-147760

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Dyrk1A-IN-2

Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC₅₀ of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity.

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CAS No.: 2459657-37-3
Formule: C₂₇H₃₄N₆O₃
Masse moléculaire:490.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Dyrk1A-IN-2 Chemical Structure

CAS No.: 2459657-37-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC₅₀ of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity^[1].

IC₅₀ & Target

DYRK1A

37 nM (EC₅₀)

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	2962 nM Compound: 63	Cytotoxicity against human HEK293T cells transfected with DYRK1A co-tranfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as reduction in luciferase activity by measuring cell number Cytotoxicity against human HEK293T cells transfected with DYRK1A co-tranfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as reduction in luciferase activity by measuring cell number	[PMID: 31757680]
HEK-293T	EC₅₀	37 nM Compound: 63	Inhibition of human DYRK1A transfected in HEK293T cells co-transfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as derepression of NFAT-dependent luciferase activity measured after 48 hrs by luciferase assay Inhibition of human DYRK1A transfected in HEK293T cells co-transfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as derepression of NFAT-dependent luciferase activity measured after 48 hrs by luciferase assay	[PMID: 31757680]

Chemical Information

CAS No. 2459657-37-3
Masse moléculaire 490.60
Formule C₂₇H₃₄N₆O₃
SMILES

CCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@@H]4CC[C@H](CC4)CN5CCOCC5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Allegretti PA, et al. Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 1;28(1):115193. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Dyrk1A-IN-2

Voir tous les produits spécifiques à Isoform DYRK

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Dyrk1A-IN-2 Related Classifications

HY-147760 Related Classifications

Bioz

Keywords

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