DYRK1

DYRK1 Related Products (27):

By Type:	Pan (15) Selective (5)

Cat. No.	Product Name	Effect	Purity

HY-N0737A

Harmine	Inhibitor	99.93%
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities.

HY-12277

AZ191	Inhibitor	99.98%
AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC₅₀ of 17 nM.

HY-U00439A

Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%
Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-112296

T025	Inhibitor	98.84%
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with K_d values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively.

HY-115677

ILK-IN-3	Inhibitor	99.57%
ILK-IN-3 is an orally active integrin linked kinase (ILK) inhibitor.

HY-15951

ML167	Inhibitor	98.62%
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC₅₀ of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.

HY-132308

DYRK1-IN-1	Inhibitor	99.62%
DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor.

HY-142295

GNF2133	Inhibitor	98.49%
GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC₅₀s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively.

HY-117391

AZ-Dyrk1B-33	Inhibitor	99.95%
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC₅₀ of 7 nM.

HY-N0737

Harmine hydrochloride	Inhibitor	98.79%
Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities.

HY-111379

EHT 5372	Inhibitor
EHT 5372 is a highly potent and selective inhibitor of DYRK's family kinases with IC₅₀s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, and 221 nM for DYRK1A, DYRK1B, DYRK2, DYRK3, CLK1, CLK2, CLK4, GSK-3α, and GSK-3β, respectively.

HY-12828A

KH-CB20	Inhibitor	99.66%
KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC₅₀ of 16.5 nM for CLK1.

HY-129492

GNF4877	Inhibitor	98.85%
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC₅₀s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC₅₀ of 0.66 μM for mouse β (R7T1) cells).

HY-128758

DYRKs-IN-1	Inhibitor
DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC₅₀s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively.

HY-128758A

DYRKs-IN-1 hydrochloride	Inhibitor	99.70%
DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC₅₀s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively.

HY-101029A

MBM-55S	Inhibitor
MBM-55S is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 1 nM.

HY-146337

Dyrk1A/B-IN-1	Inhibitor
Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with K_is of 67.8 nM and 237.9 nM, and IC₅₀s of 1.1 μM and 0.8 μM, respectively.

HY-146587

Haspin-IN-2	Inhibitor
Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC₅₀ of 50 nM.

HY-144614

JH-XVII-10	Inhibitor
JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC₅₀s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively.

HY-144695

Dyrk1A/α-synuclein-IN-1	Inhibitor
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC₅₀ values of 177 nM and 10.5 µM, respectively.

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