ON 108600
Based on 1 Customer Validation
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity.
For research use only. We do not sell to patients.
- Purity: 98.65%
- CAS No.: 1585246-23-6
- Formula: C22H14Cl2N2O6S2
- Molecular Weight:537.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DYRK2 0.028 μM (IC50) |
DYRK1A 0.016 μM (IC50) |
DYRK1B 0.007 μM (IC50) |
CK2α2 0.005 μM (IC50) |
CK2α1 0.05 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-22 | IC50 |
1 μM
Compound: 29; 108600
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Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 36876904] |
Chemical Information
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CAS No. 1585246-23-6
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Appearance Solid
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Molecular Weight 537.39
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Formula C22H14Cl2N2O6S2
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Color Brown to reddish brown
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SMILES
ClC(C=CC=C1Cl)=C1CS(=O)(C2=CC=C(S/C(C(N3)=O)=C\C4=CC([N+]([O-])=O)=C(C=C4)O)C3=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (186.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8608 mL | 9.3042 mL | 18.6085 mL | 46.5211 mL |
| 5 mM | 0.3722 mL | 1.8608 mL | 3.7217 mL | 9.3042 mL | |
| 10 mM | 0.1861 mL | 0.9304 mL | 1.8608 mL | 4.6521 mL | |
| 15 mM | 0.1241 mL | 0.6203 mL | 1.2406 mL | 3.1014 mL | |
| 20 mM | 0.0930 mL | 0.4652 mL | 0.9304 mL | 2.3261 mL | |
| 25 mM | 0.0744 mL | 0.3722 mL | 0.7443 mL | 1.8608 mL | |
| 30 mM | 0.0620 mL | 0.3101 mL | 0.6203 mL | 1.5507 mL | |
| 40 mM | 0.0465 mL | 0.2326 mL | 0.4652 mL | 1.1630 mL | |
| 50 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9304 mL | |
| 60 mM | 0.0310 mL | 0.1551 mL | 0.3101 mL | 0.7754 mL | |
| 80 mM | 0.0233 mL | 0.1163 mL | 0.2326 mL | 0.5815 mL | |
| 100 mM | 0.0186 mL | 0.0930 mL | 0.1861 mL | 0.4652 mL |
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