DYRK1B
DYRK1B, better known as MIRK (minibrain-related kinase), is a predominantly nuclear member of the DYRK1 branch enriched in skeletal muscle, brain, and testis. It undergoes activation-loop tyrosine autophosphorylation and then phosphorylates serine/threonine substrates connected to cell-cycle withdrawal and differentiation, contributing to p27-mediated quiescence and to myogenic gene programs. MIRK activity is restrained by chaperone complexes and can be induced under stress conditions. Elevated DYRK1B expression has been reported in pancreatic ductal adenocarcinoma, prostate cancer, and other malignancies, where it supports the survival of slowly cycling cells. The recombinant protein is used in differentiation models and oncology inhibitor screens.
-
DYRK1B Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
