DYRK1B Protein, Human (Active, sf9, GST, Flag)
DYRK1B protein has dual serine/threonine and tyrosine kinase activities. DYRK1B, Human (Active, sf9, GST, Flag) is the recombinant human-derived DYRK1B protein, expressed by Sf9 insect cells, with labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
DYRK1B protein has dual serine/threonine and tyrosine kinase activities. DYRK1B, Human (Active, sf9, GST, Flag) is the recombinant human-derived DYRK1B protein, expressed by Sf9 insect cells, with labeled tag.
Background
DYRK1B, a dual-specificity kinase endowed with both serine/threonine and tyrosine kinase activities, assumes a critical role in cellular processes, particularly in ribosomal DNA (rDNA) double-strand break repair and the maintenance of rDNA copy number. During instances of DNA damage, DYRK1B orchestrates transcription silencing by phosphorylating and promoting the accumulation of double-strand breaks through the histone methyltransferase EHMT2. Beyond its involvement in DNA repair, DYRK1B exhibits versatile functions, enhancing the transcriptional activity of TCF1/HNF1A and FOXO1, inhibiting epithelial cell migration, and promoting survival of colon carcinoma cells in mitogen-poor environments. Moreover, DYRK1B modulates signaling pathways such as SHH and WNT1, thereby facilitating adipogenesis, and concurrently stimulates the expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). This multifaceted kinase emerges as a key regulator in diverse cellular processes, contributing to both DNA repair mechanisms and the modulation of crucial signaling pathways.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST;C-Flag
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Accession
Q9Y463-1 (M1-S629)
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Gene ID9149
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Molecular Construction
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N-term
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GST
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DYRK1B (M1-S629)
Accession # Q9Y463-1 -
Flag
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
DYRK1B; Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B; Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B; Mirk Protein Kinase; MIRK; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B; Minibrain-Related Kinase; D
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AA Sequence
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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